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Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense stroma, which has a fundamental role in tumor progression. Fibronectin (FN1) is the main constituent of the tumor stroma in pancreatic cancer. This study aimed to explore the association between FN1 and clinic...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368702/ https://www.ncbi.nlm.nih.gov/pubmed/30736807 http://dx.doi.org/10.1186/s12957-019-1574-z |
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author | Hu, Dingyuan Ansari, Daniel Zhou, Qimin Sasor, Agata Said Hilmersson, Katarzyna Andersson, Roland |
author_facet | Hu, Dingyuan Ansari, Daniel Zhou, Qimin Sasor, Agata Said Hilmersson, Katarzyna Andersson, Roland |
author_sort | Hu, Dingyuan |
collection | PubMed |
description | BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense stroma, which has a fundamental role in tumor progression. Fibronectin (FN1) is the main constituent of the tumor stroma in pancreatic cancer. This study aimed to explore the association between FN1 and clinicopathological characteristics and disease survival. METHODS: Formalin-fixed paraffin-embedded tissue samples from 138 patients with PDAC were constructed into a tissue microarray, followed by immunohistochemical analysis with a recombinant monoclonal FN1 antibody. Chi-square test or Fisher’s exact test were used for comparison of FN1 expression and relevant clinicopathological parameters. Kaplan-Meier survival curves and Cox regression analyses were used to assess the association between FN1 and survival. RESULTS: FN1 was detected in the stromal compartment in most cases (117/138, 84.8%). Compared to the low FN1 expression group, the high FN1 expression group had significantly larger tumor size (P = 0.002), more advanced T stage (P = 0.039) and N stage (P = 0.009), and also worse AJCC stage (P = 0.003). However, stromal FN1 expression was not associated with disease-free survival or overall survival. CONCLUSIONS: This study suggests that high stromal FN1 expression is associated with aggressive tumor characteristics in patients with resected PDAC. However, no association between FN1 expression and survival was found. |
format | Online Article Text |
id | pubmed-6368702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63687022019-02-15 Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma Hu, Dingyuan Ansari, Daniel Zhou, Qimin Sasor, Agata Said Hilmersson, Katarzyna Andersson, Roland World J Surg Oncol Research BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense stroma, which has a fundamental role in tumor progression. Fibronectin (FN1) is the main constituent of the tumor stroma in pancreatic cancer. This study aimed to explore the association between FN1 and clinicopathological characteristics and disease survival. METHODS: Formalin-fixed paraffin-embedded tissue samples from 138 patients with PDAC were constructed into a tissue microarray, followed by immunohistochemical analysis with a recombinant monoclonal FN1 antibody. Chi-square test or Fisher’s exact test were used for comparison of FN1 expression and relevant clinicopathological parameters. Kaplan-Meier survival curves and Cox regression analyses were used to assess the association between FN1 and survival. RESULTS: FN1 was detected in the stromal compartment in most cases (117/138, 84.8%). Compared to the low FN1 expression group, the high FN1 expression group had significantly larger tumor size (P = 0.002), more advanced T stage (P = 0.039) and N stage (P = 0.009), and also worse AJCC stage (P = 0.003). However, stromal FN1 expression was not associated with disease-free survival or overall survival. CONCLUSIONS: This study suggests that high stromal FN1 expression is associated with aggressive tumor characteristics in patients with resected PDAC. However, no association between FN1 expression and survival was found. BioMed Central 2019-02-08 /pmc/articles/PMC6368702/ /pubmed/30736807 http://dx.doi.org/10.1186/s12957-019-1574-z Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Hu, Dingyuan Ansari, Daniel Zhou, Qimin Sasor, Agata Said Hilmersson, Katarzyna Andersson, Roland Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma |
title | Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma |
title_full | Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma |
title_fullStr | Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma |
title_full_unstemmed | Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma |
title_short | Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma |
title_sort | stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368702/ https://www.ncbi.nlm.nih.gov/pubmed/30736807 http://dx.doi.org/10.1186/s12957-019-1574-z |
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