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Large-scale production of tauroursodeoxycholic acid products through fermentation optimization of engineered Escherichia coli cell factory

BACKGROUND: Bear bile powder is a valuable medicinal material characterized by high content of tauroursodeoxycholic acid (TUDCA) at a certain ratio to taurochenodeoxycholic acid (TCDCA). We had created an engineered E. coli harboring two-step bidirectional oxidative and reductive enzyme-catalyzing p...

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Detalles Bibliográficos
Autores principales:	Xu, Yingpeng, Yang, Li, Zhao, Shujuan, Wang, Zhengtao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368744/ https://www.ncbi.nlm.nih.gov/pubmed/30736766 http://dx.doi.org/10.1186/s12934-019-1076-2

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