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Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets

BACKGROUND: The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF). Following ligand binding, EGFR heterodimerizes with other HER family members, such as HER2 (human epidermal gro...

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Detalles Bibliográficos
Autores principales:	Nava, Miguel, Dutta, Pranabananda, Zemke, Nathan R., Farias-Eisner, Robin, Vadgama, Jaydutt V., Wu, Yanyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368760/ https://www.ncbi.nlm.nih.gov/pubmed/30736768 http://dx.doi.org/10.1186/s12920-019-0477-8

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