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Efficacy of Hematological and Coagulation Parameters in the Diagnosis and Prognosis of Patients with Acute Coronary Syndrome
Background : The diagnosis and management of acute coronary syndrome (ACS) have improved significantly over the past few decades; however, the recognition of myocardial ischemia still proves to be a dilemma for cardiologists. The aim of this study was to determine the role of hematological and coagu...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences, 2006-
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368913/ https://www.ncbi.nlm.nih.gov/pubmed/30745924 |
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author | Adam, Arsalan Majeed Ali, Muhammad Armughan Shah, Arshad Ali Rizvi, Ather Hasan Rehan, Aiman Godil, Ansab Abbas, Abdul Haseeb Durrani, Najam Ul Ain Shaikh, Ali Tariq Mallick, Muhammad Saad Ali Lashari, Muhammad Nawaz |
author_facet | Adam, Arsalan Majeed Ali, Muhammad Armughan Shah, Arshad Ali Rizvi, Ather Hasan Rehan, Aiman Godil, Ansab Abbas, Abdul Haseeb Durrani, Najam Ul Ain Shaikh, Ali Tariq Mallick, Muhammad Saad Ali Lashari, Muhammad Nawaz |
author_sort | Adam, Arsalan Majeed |
collection | PubMed |
description | Background : The diagnosis and management of acute coronary syndrome (ACS) have improved significantly over the past few decades; however, the recognition of myocardial ischemia still proves to be a dilemma for cardiologists. The aim of this study was to determine the role of hematological and coagulation parameters in the diagnosis and prognosis of patients with ACS. Methods: This prospective study recruited 250 patients with ACS and 250 healthy controls. The diagnostic role of hematological and coagulation parameters was assessed by comparing the patients with ACS with the control group. The relationships between these parameters and mortality were determined by dividing the patients into 2 groups: Group A (discharged) and Group B (patients who died within 30 days of follow-up). Multivariate Cox regression analysis was performed to calculate the hazard ratio (HR). Results: The mean age of the patients was 55.14±10.71 years, and 65.2% of them were male. Prothrombin time (P<0.001), activated partial thromboplastin time (P<0.001), mean platelet volume (MPV) (P<0.001), white blood cell (WBC) count (P<0.001), and red blood cell distribution width (RDW) (P<0.001) were significantly higher in the case group than in the control group. WBC count (P<0.001), RDW (P<0.001), and MPV (P<0.001) were significantly higher in the controls than in the case group. The Cox regression model showed that RDW above 16.55% (HR=6.8), MPV greater than 11.25 fL (HR=2.6), and WBC higher than 10.55×10(3)/μL (HR=6.3) were the independent predictors of mortality. Conclusion: In addition to being the independent predictors of short-term mortality, RDW, WBC, and MPV when used together with the coagulation profile may aid in the diagnosis of ACS in patients presenting with chest pain. |
format | Online Article Text |
id | pubmed-6368913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Tehran University of Medical Sciences, 2006- |
record_format | MEDLINE/PubMed |
spelling | pubmed-63689132019-02-11 Efficacy of Hematological and Coagulation Parameters in the Diagnosis and Prognosis of Patients with Acute Coronary Syndrome Adam, Arsalan Majeed Ali, Muhammad Armughan Shah, Arshad Ali Rizvi, Ather Hasan Rehan, Aiman Godil, Ansab Abbas, Abdul Haseeb Durrani, Najam Ul Ain Shaikh, Ali Tariq Mallick, Muhammad Saad Ali Lashari, Muhammad Nawaz J Tehran Heart Cent Original Article Background : The diagnosis and management of acute coronary syndrome (ACS) have improved significantly over the past few decades; however, the recognition of myocardial ischemia still proves to be a dilemma for cardiologists. The aim of this study was to determine the role of hematological and coagulation parameters in the diagnosis and prognosis of patients with ACS. Methods: This prospective study recruited 250 patients with ACS and 250 healthy controls. The diagnostic role of hematological and coagulation parameters was assessed by comparing the patients with ACS with the control group. The relationships between these parameters and mortality were determined by dividing the patients into 2 groups: Group A (discharged) and Group B (patients who died within 30 days of follow-up). Multivariate Cox regression analysis was performed to calculate the hazard ratio (HR). Results: The mean age of the patients was 55.14±10.71 years, and 65.2% of them were male. Prothrombin time (P<0.001), activated partial thromboplastin time (P<0.001), mean platelet volume (MPV) (P<0.001), white blood cell (WBC) count (P<0.001), and red blood cell distribution width (RDW) (P<0.001) were significantly higher in the case group than in the control group. WBC count (P<0.001), RDW (P<0.001), and MPV (P<0.001) were significantly higher in the controls than in the case group. The Cox regression model showed that RDW above 16.55% (HR=6.8), MPV greater than 11.25 fL (HR=2.6), and WBC higher than 10.55×10(3)/μL (HR=6.3) were the independent predictors of mortality. Conclusion: In addition to being the independent predictors of short-term mortality, RDW, WBC, and MPV when used together with the coagulation profile may aid in the diagnosis of ACS in patients presenting with chest pain. Tehran University of Medical Sciences, 2006- 2018-07 /pmc/articles/PMC6368913/ /pubmed/30745924 Text en Copyright © 2015 Tehran Heart Center, Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Adam, Arsalan Majeed Ali, Muhammad Armughan Shah, Arshad Ali Rizvi, Ather Hasan Rehan, Aiman Godil, Ansab Abbas, Abdul Haseeb Durrani, Najam Ul Ain Shaikh, Ali Tariq Mallick, Muhammad Saad Ali Lashari, Muhammad Nawaz Efficacy of Hematological and Coagulation Parameters in the Diagnosis and Prognosis of Patients with Acute Coronary Syndrome |
title | Efficacy of Hematological and Coagulation Parameters in the Diagnosis and Prognosis of Patients with Acute Coronary Syndrome |
title_full | Efficacy of Hematological and Coagulation Parameters in the Diagnosis and Prognosis of Patients with Acute Coronary Syndrome |
title_fullStr | Efficacy of Hematological and Coagulation Parameters in the Diagnosis and Prognosis of Patients with Acute Coronary Syndrome |
title_full_unstemmed | Efficacy of Hematological and Coagulation Parameters in the Diagnosis and Prognosis of Patients with Acute Coronary Syndrome |
title_short | Efficacy of Hematological and Coagulation Parameters in the Diagnosis and Prognosis of Patients with Acute Coronary Syndrome |
title_sort | efficacy of hematological and coagulation parameters in the diagnosis and prognosis of patients with acute coronary syndrome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368913/ https://www.ncbi.nlm.nih.gov/pubmed/30745924 |
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