Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea

We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS outbreak in South Korea at 2015. The neutralizing activity in serum was measured by pseudo...

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Autores principales: Choi, Jun Yong, Oh, Jin Ok, Ahn, Jin Young, Choi, Heun, Kim, Jung Ho, Seong, Hye, Jeong, Su Jin, Ku, Nam Su, Yeom, Joon-Sup, Choi, Jae-Phil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Vaccine Society 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369131/
https://www.ncbi.nlm.nih.gov/pubmed/30775355
http://dx.doi.org/10.7774/cevr.2019.8.1.86
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author Choi, Jun Yong
Oh, Jin Ok
Ahn, Jin Young
Choi, Heun
Kim, Jung Ho
Seong, Hye
Jeong, Su Jin
Ku, Nam Su
Yeom, Joon-Sup
Choi, Jae-Phil
author_facet Choi, Jun Yong
Oh, Jin Ok
Ahn, Jin Young
Choi, Heun
Kim, Jung Ho
Seong, Hye
Jeong, Su Jin
Ku, Nam Su
Yeom, Joon-Sup
Choi, Jae-Phil
author_sort Choi, Jun Yong
collection PubMed
description We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS outbreak in South Korea at 2015. The neutralizing activity in serum was measured by pseudovirus inhibition assays. Three-fold diluted serum of subjects showed only 9.7%, 10.3%, and 2.2% reductions in relative light units. So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection.
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spelling pubmed-63691312019-02-17 Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea Choi, Jun Yong Oh, Jin Ok Ahn, Jin Young Choi, Heun Kim, Jung Ho Seong, Hye Jeong, Su Jin Ku, Nam Su Yeom, Joon-Sup Choi, Jae-Phil Clin Exp Vaccine Res Brief Communication We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS outbreak in South Korea at 2015. The neutralizing activity in serum was measured by pseudovirus inhibition assays. Three-fold diluted serum of subjects showed only 9.7%, 10.3%, and 2.2% reductions in relative light units. So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection. The Korean Vaccine Society 2019-01 2019-01-31 /pmc/articles/PMC6369131/ /pubmed/30775355 http://dx.doi.org/10.7774/cevr.2019.8.1.86 Text en © Korean Vaccine Society. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Choi, Jun Yong
Oh, Jin Ok
Ahn, Jin Young
Choi, Heun
Kim, Jung Ho
Seong, Hye
Jeong, Su Jin
Ku, Nam Su
Yeom, Joon-Sup
Choi, Jae-Phil
Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea
title Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea
title_full Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea
title_fullStr Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea
title_full_unstemmed Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea
title_short Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea
title_sort absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from mers in south korea
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369131/
https://www.ncbi.nlm.nih.gov/pubmed/30775355
http://dx.doi.org/10.7774/cevr.2019.8.1.86
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