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Temozolomide Induced Hypermutation in Glioma: Evolutionary Mechanisms and Therapeutic Opportunities

Glioma are the most common type of malignant brain tumor, with glioblastoma (GBM) representing the most common and most lethal type of glioma. Surgical resection followed by radiotherapy and chemotherapy using the alkylating agent Temozolomide (TMZ) remain the mainstay of treatment for glioma. While...

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Detalles Bibliográficos
Autores principales:	Daniel, Paul, Sabri, Siham, Chaddad, Ahmad, Meehan, Brian, Jean-Claude, Bertrand, Rak, Janusz, Abdulkarim, Bassam S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369148/ https://www.ncbi.nlm.nih.gov/pubmed/30778375 http://dx.doi.org/10.3389/fonc.2019.00041

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