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Humanized Mice Reveal New Insights Into the Thymic Selection of Human Autoreactive CD8(+) T Cells

Thymic selection constitutes the first checkpoint in T-cell development to purge autoreactive T cells. Most of our understanding of this process comes from animal models because of the challenges of studying thymopoiesis and how T cell receptor (TCR) specificity impacts thymocyte phenotype in humans...

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Detalles Bibliográficos
Autores principales:	Li, Yang, Teteloshvili, Nato, Tan, Shulian, Rao, Samhita, Han, Arnold, Yang, Yong-Guang, Creusot, Rémi J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369192/ https://www.ncbi.nlm.nih.gov/pubmed/30778347 http://dx.doi.org/10.3389/fimmu.2019.00063

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