Knockdown of USF1 Inhibits the Vasculogenic Mimicry of Glioma Cells via Stimulating SNHG16/miR-212-3p and linc00667/miR-429 Axis

The anti-angiogenic treatment of malignant glioma cells is an effective method to treat high-grade gliomas. However, due to the presence of vasculogenic mimicry (VM), the anti-angiogenic treatment of gliomas is not significantly effective in improving overall patient median survival. Therefore, this...

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Autores principales: Wang, Di, Zheng, Jian, Liu, Xiaobai, Xue, Yixue, Liu, Libo, Ma, Jun, He, Qianru, Li, Zhen, Cai, Heng, Liu, Yunhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369224/
https://www.ncbi.nlm.nih.gov/pubmed/30743215
http://dx.doi.org/10.1016/j.omtn.2018.12.017
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author Wang, Di
Zheng, Jian
Liu, Xiaobai
Xue, Yixue
Liu, Libo
Ma, Jun
He, Qianru
Li, Zhen
Cai, Heng
Liu, Yunhui
author_facet Wang, Di
Zheng, Jian
Liu, Xiaobai
Xue, Yixue
Liu, Libo
Ma, Jun
He, Qianru
Li, Zhen
Cai, Heng
Liu, Yunhui
author_sort Wang, Di
collection PubMed
description The anti-angiogenic treatment of malignant glioma cells is an effective method to treat high-grade gliomas. However, due to the presence of vasculogenic mimicry (VM), the anti-angiogenic treatment of gliomas is not significantly effective in improving overall patient median survival. Therefore, this study investigated the mechanism of mimic formation of angiogenesis in gliomas. The results of this experiment indicate that the expression of upstream transcription factor 1 (USF1) is upregulated in glioma tissues and cells. USF1 knockdown inhibits the proliferation, migration, invasion, VM, and expression of VM-associated proteins in glioma cells by stimulating SNHG16 and linc00667. These two long non-coding RNAs (lncRNAs) regulate ALHD1A1 through the competing endogenous RNA (ceRNA) mechanism influencing the VM of glioma. This study is the first to demonstrate that the USF1/SNHG16/miR-212-3p/ALDH1A1 (aldehyde dehydrogenase-1) and USF1/linc00667/miR-429/ALDH1A1 axis regulates the VM of glioma cells, and these findings might provide a novel strategy for glioma treatment.
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spelling pubmed-63692242019-02-20 Knockdown of USF1 Inhibits the Vasculogenic Mimicry of Glioma Cells via Stimulating SNHG16/miR-212-3p and linc00667/miR-429 Axis Wang, Di Zheng, Jian Liu, Xiaobai Xue, Yixue Liu, Libo Ma, Jun He, Qianru Li, Zhen Cai, Heng Liu, Yunhui Mol Ther Nucleic Acids Article The anti-angiogenic treatment of malignant glioma cells is an effective method to treat high-grade gliomas. However, due to the presence of vasculogenic mimicry (VM), the anti-angiogenic treatment of gliomas is not significantly effective in improving overall patient median survival. Therefore, this study investigated the mechanism of mimic formation of angiogenesis in gliomas. The results of this experiment indicate that the expression of upstream transcription factor 1 (USF1) is upregulated in glioma tissues and cells. USF1 knockdown inhibits the proliferation, migration, invasion, VM, and expression of VM-associated proteins in glioma cells by stimulating SNHG16 and linc00667. These two long non-coding RNAs (lncRNAs) regulate ALHD1A1 through the competing endogenous RNA (ceRNA) mechanism influencing the VM of glioma. This study is the first to demonstrate that the USF1/SNHG16/miR-212-3p/ALDH1A1 (aldehyde dehydrogenase-1) and USF1/linc00667/miR-429/ALDH1A1 axis regulates the VM of glioma cells, and these findings might provide a novel strategy for glioma treatment. American Society of Gene & Cell Therapy 2019-01-15 /pmc/articles/PMC6369224/ /pubmed/30743215 http://dx.doi.org/10.1016/j.omtn.2018.12.017 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Wang, Di
Zheng, Jian
Liu, Xiaobai
Xue, Yixue
Liu, Libo
Ma, Jun
He, Qianru
Li, Zhen
Cai, Heng
Liu, Yunhui
Knockdown of USF1 Inhibits the Vasculogenic Mimicry of Glioma Cells via Stimulating SNHG16/miR-212-3p and linc00667/miR-429 Axis
title Knockdown of USF1 Inhibits the Vasculogenic Mimicry of Glioma Cells via Stimulating SNHG16/miR-212-3p and linc00667/miR-429 Axis
title_full Knockdown of USF1 Inhibits the Vasculogenic Mimicry of Glioma Cells via Stimulating SNHG16/miR-212-3p and linc00667/miR-429 Axis
title_fullStr Knockdown of USF1 Inhibits the Vasculogenic Mimicry of Glioma Cells via Stimulating SNHG16/miR-212-3p and linc00667/miR-429 Axis
title_full_unstemmed Knockdown of USF1 Inhibits the Vasculogenic Mimicry of Glioma Cells via Stimulating SNHG16/miR-212-3p and linc00667/miR-429 Axis
title_short Knockdown of USF1 Inhibits the Vasculogenic Mimicry of Glioma Cells via Stimulating SNHG16/miR-212-3p and linc00667/miR-429 Axis
title_sort knockdown of usf1 inhibits the vasculogenic mimicry of glioma cells via stimulating snhg16/mir-212-3p and linc00667/mir-429 axis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369224/
https://www.ncbi.nlm.nih.gov/pubmed/30743215
http://dx.doi.org/10.1016/j.omtn.2018.12.017
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