Bivalent Ligands for Protein Degradation in Drug Discovery

Targeting the “undruggable” proteome remains one of the big challenges in drug discovery. Recent innovations in the field of targeted protein degradation and manipulation of the ubiquitin-proteasome system open up new therapeutic approaches for disorders that cannot be targeted with conventional inh...

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Detalles Bibliográficos
Autores principales: Scheepstra, Marcel, Hekking, Koen F.W., van Hijfte, Luc, Folmer, Rutger H.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369262/
https://www.ncbi.nlm.nih.gov/pubmed/30788082
http://dx.doi.org/10.1016/j.csbj.2019.01.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369262/
https://www.ncbi.nlm.nih.gov/pubmed/30788082
http://dx.doi.org/10.1016/j.csbj.2019.01.006

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