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Influence of Transmembrane Helix Mutations on Cytochrome P450-Membrane Interactions and Function

Human cytochrome P450 (CYP) enzymes play an important role in the metabolism of drugs, steroids, fatty acids, and xenobiotics. Microsomal CYPs are anchored in the endoplasmic reticulum membrane by an N-terminal transmembrane (TM) helix that is connected to the globular catalytic domain by a flexible...

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Detalles Bibliográficos
Autores principales:	Mustafa, Ghulam, Nandekar, Prajwal P., Camp, Tyler J., Bruce, Neil J., Gregory, Michael C., Sligar, Stephen G., Wade, Rebecca C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Biophysical Society 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369400/ https://www.ncbi.nlm.nih.gov/pubmed/30658838 http://dx.doi.org/10.1016/j.bpj.2018.12.014

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