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A high burden of cytomegalovirus marks poor vascular health in transplant recipients more clearly than in the general population
OBJECTIVES: Meta‐analyses have now confirmed that persistent infections with cytomegalovirus (CMV) can accelerate the onset of diseases of ageing, notably cardiovascular pathologies. We address the circumstances in which the association may be strong enough to warrant intervention to reduce the vira...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369563/ https://www.ncbi.nlm.nih.gov/pubmed/30788107 http://dx.doi.org/10.1002/cti2.1043 |
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author | Lee, Silvia Brook, Emily Affandi, Jacquita Howson, Prue Tanudjaja, Selita Agnes Dhaliwal, Satvinder Irish, Ashley Price, Patricia |
author_facet | Lee, Silvia Brook, Emily Affandi, Jacquita Howson, Prue Tanudjaja, Selita Agnes Dhaliwal, Satvinder Irish, Ashley Price, Patricia |
author_sort | Lee, Silvia |
collection | PubMed |
description | OBJECTIVES: Meta‐analyses have now confirmed that persistent infections with cytomegalovirus (CMV) can accelerate the onset of diseases of ageing, notably cardiovascular pathologies. We address the circumstances in which the association may be strong enough to warrant intervention to reduce the viral burden. RESULTS: We compare markers of the burden of CMV with established indices of vascular pathology in healthy adults (n = 82) and in renal transplant recipients (RTR; n = 81). Levels of all inflammatory and vascular biomarkers and CMV antibodies were higher in RTR, and flow‐mediated dilation (FMD) values were lower indicating inferior endothelial function. In multivariable regression models without adjustment for estimated glomerular filtration rate (eGFR), CMV antibody levels, age and gender were independently associated with FMD in RTR, whilst only CRP associated with FMD in healthy adults. After adjustment for eGFR, associations between CMV antibody and FMD in RTR were reduced. METHODS: Carotid intima‐media thickness, FMD, eGFR and plasma levels of CMV antibodies (reactive with a lysate, CMV IE‐1 or CMV gB), ICAM‐1, VCAM‐1, P‐selectin, sIFNαR2, sTNFR1, sCD14 and CRP were determined. CONCLUSION: Levels of CMV antibody predict declining endothelial health in RTR and not in healthy adults, presumably by reflecting a high burden of CMV. The levels of CMV antibodies were a poor reflection of plasma biomarkers thought to reflect ‘inflammaging’ or vascular damage. |
format | Online Article Text |
id | pubmed-6369563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63695632019-02-20 A high burden of cytomegalovirus marks poor vascular health in transplant recipients more clearly than in the general population Lee, Silvia Brook, Emily Affandi, Jacquita Howson, Prue Tanudjaja, Selita Agnes Dhaliwal, Satvinder Irish, Ashley Price, Patricia Clin Transl Immunology Original Articles OBJECTIVES: Meta‐analyses have now confirmed that persistent infections with cytomegalovirus (CMV) can accelerate the onset of diseases of ageing, notably cardiovascular pathologies. We address the circumstances in which the association may be strong enough to warrant intervention to reduce the viral burden. RESULTS: We compare markers of the burden of CMV with established indices of vascular pathology in healthy adults (n = 82) and in renal transplant recipients (RTR; n = 81). Levels of all inflammatory and vascular biomarkers and CMV antibodies were higher in RTR, and flow‐mediated dilation (FMD) values were lower indicating inferior endothelial function. In multivariable regression models without adjustment for estimated glomerular filtration rate (eGFR), CMV antibody levels, age and gender were independently associated with FMD in RTR, whilst only CRP associated with FMD in healthy adults. After adjustment for eGFR, associations between CMV antibody and FMD in RTR were reduced. METHODS: Carotid intima‐media thickness, FMD, eGFR and plasma levels of CMV antibodies (reactive with a lysate, CMV IE‐1 or CMV gB), ICAM‐1, VCAM‐1, P‐selectin, sIFNαR2, sTNFR1, sCD14 and CRP were determined. CONCLUSION: Levels of CMV antibody predict declining endothelial health in RTR and not in healthy adults, presumably by reflecting a high burden of CMV. The levels of CMV antibodies were a poor reflection of plasma biomarkers thought to reflect ‘inflammaging’ or vascular damage. John Wiley and Sons Inc. 2019-02-11 /pmc/articles/PMC6369563/ /pubmed/30788107 http://dx.doi.org/10.1002/cti2.1043 Text en © 2019 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australasian Society for Immunology Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Lee, Silvia Brook, Emily Affandi, Jacquita Howson, Prue Tanudjaja, Selita Agnes Dhaliwal, Satvinder Irish, Ashley Price, Patricia A high burden of cytomegalovirus marks poor vascular health in transplant recipients more clearly than in the general population |
title | A high burden of cytomegalovirus marks poor vascular health in transplant recipients more clearly than in the general population |
title_full | A high burden of cytomegalovirus marks poor vascular health in transplant recipients more clearly than in the general population |
title_fullStr | A high burden of cytomegalovirus marks poor vascular health in transplant recipients more clearly than in the general population |
title_full_unstemmed | A high burden of cytomegalovirus marks poor vascular health in transplant recipients more clearly than in the general population |
title_short | A high burden of cytomegalovirus marks poor vascular health in transplant recipients more clearly than in the general population |
title_sort | high burden of cytomegalovirus marks poor vascular health in transplant recipients more clearly than in the general population |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369563/ https://www.ncbi.nlm.nih.gov/pubmed/30788107 http://dx.doi.org/10.1002/cti2.1043 |
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