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Antioxidant, antibacterial, antidiarrheal and antipyretic activities of organic crude fractions of Commelina paludosa
BACKGROUND: The herb, Commelina paludosa (CP) Blume (Family-Commelinaceae) is medicinally used by the traditional practitioners in Bangladesh. However, there is a lack of scientific evidence on this medicinal herb. AIM AND OBJECTIVES: This study aimed to evaluate the phytochemical and pharmacologica...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369604/ https://www.ncbi.nlm.nih.gov/pubmed/30783365 http://dx.doi.org/10.4103/ayu.AYU_213_17 |
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author | Riaz, Thoufiqul Alam Hossain, Shahdat Ferdous, Jannatul Hossain, Mohammad Islam, Muhammad Torequl Chae, Han-Jung Hossain, Muhammad Kamal |
author_facet | Riaz, Thoufiqul Alam Hossain, Shahdat Ferdous, Jannatul Hossain, Mohammad Islam, Muhammad Torequl Chae, Han-Jung Hossain, Muhammad Kamal |
author_sort | Riaz, Thoufiqul Alam |
collection | PubMed |
description | BACKGROUND: The herb, Commelina paludosa (CP) Blume (Family-Commelinaceae) is medicinally used by the traditional practitioners in Bangladesh. However, there is a lack of scientific evidence on this medicinal herb. AIM AND OBJECTIVES: This study aimed to evaluate the phytochemical and pharmacological activities of CP (ethanol [ECP], chloroform [CCP] and n-hexane [NHCP] of whole-plant extracts). MATERIALS AND METHODS: For this antioxidant, antimicrobial, antidiarrheal and antipyretic activities of crude extracts of CP were conducted by 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging, disc diffusion and serial dilution, castor oil-induced diarrhea and yeast powder-induced pyrexia methods respectively. RESULTS AND OBSERVATION: The results suggest that all the fractions significantly scavenged DPPH radicals. In the disc diffusion test, the zones of inhibition were observed within the range of 7 mm to 30.67 mm at 500 mg/disc. The highest zones of inhibition were observed by ECP, CCP and NHCP against Bacillus azotoformans, Lactobacillus coryifomis and Salmonella typhi respectively. NHCP was found to exert stronger antibacterial effect than the ECP and CCP. CONCLUSION: Minimum inhibitory concentrations were detected within the range of 31.25 and 250 μg/ml. Moreover, the crude fractions also showed significant (P < 0.05) antidiarrheal and antipyretic activities in Swiss mice. CP may be a good source of therapeutic components. |
format | Online Article Text |
id | pubmed-6369604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-63696042019-02-19 Antioxidant, antibacterial, antidiarrheal and antipyretic activities of organic crude fractions of Commelina paludosa Riaz, Thoufiqul Alam Hossain, Shahdat Ferdous, Jannatul Hossain, Mohammad Islam, Muhammad Torequl Chae, Han-Jung Hossain, Muhammad Kamal Ayu Pharmacological Study BACKGROUND: The herb, Commelina paludosa (CP) Blume (Family-Commelinaceae) is medicinally used by the traditional practitioners in Bangladesh. However, there is a lack of scientific evidence on this medicinal herb. AIM AND OBJECTIVES: This study aimed to evaluate the phytochemical and pharmacological activities of CP (ethanol [ECP], chloroform [CCP] and n-hexane [NHCP] of whole-plant extracts). MATERIALS AND METHODS: For this antioxidant, antimicrobial, antidiarrheal and antipyretic activities of crude extracts of CP were conducted by 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging, disc diffusion and serial dilution, castor oil-induced diarrhea and yeast powder-induced pyrexia methods respectively. RESULTS AND OBSERVATION: The results suggest that all the fractions significantly scavenged DPPH radicals. In the disc diffusion test, the zones of inhibition were observed within the range of 7 mm to 30.67 mm at 500 mg/disc. The highest zones of inhibition were observed by ECP, CCP and NHCP against Bacillus azotoformans, Lactobacillus coryifomis and Salmonella typhi respectively. NHCP was found to exert stronger antibacterial effect than the ECP and CCP. CONCLUSION: Minimum inhibitory concentrations were detected within the range of 31.25 and 250 μg/ml. Moreover, the crude fractions also showed significant (P < 0.05) antidiarrheal and antipyretic activities in Swiss mice. CP may be a good source of therapeutic components. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6369604/ /pubmed/30783365 http://dx.doi.org/10.4103/ayu.AYU_213_17 Text en Copyright: © 2019 AYU (An International Quarterly Journal of Research in Ayurveda) http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Pharmacological Study Riaz, Thoufiqul Alam Hossain, Shahdat Ferdous, Jannatul Hossain, Mohammad Islam, Muhammad Torequl Chae, Han-Jung Hossain, Muhammad Kamal Antioxidant, antibacterial, antidiarrheal and antipyretic activities of organic crude fractions of Commelina paludosa |
title | Antioxidant, antibacterial, antidiarrheal and antipyretic activities of organic crude fractions of Commelina paludosa |
title_full | Antioxidant, antibacterial, antidiarrheal and antipyretic activities of organic crude fractions of Commelina paludosa |
title_fullStr | Antioxidant, antibacterial, antidiarrheal and antipyretic activities of organic crude fractions of Commelina paludosa |
title_full_unstemmed | Antioxidant, antibacterial, antidiarrheal and antipyretic activities of organic crude fractions of Commelina paludosa |
title_short | Antioxidant, antibacterial, antidiarrheal and antipyretic activities of organic crude fractions of Commelina paludosa |
title_sort | antioxidant, antibacterial, antidiarrheal and antipyretic activities of organic crude fractions of commelina paludosa |
topic | Pharmacological Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369604/ https://www.ncbi.nlm.nih.gov/pubmed/30783365 http://dx.doi.org/10.4103/ayu.AYU_213_17 |
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