Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires

MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical for downstream processing and mature miRNA target specificity. To understand how pri-miRNA sequence and structure influence Drosha cleavage, we studied the maturation of three pri-miR-9 paralogs, which encode...

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Detalles Bibliográficos
Autores principales: Bofill-De Ros, Xavier, Kasprzak, Wojciech K., Bhandari, Yuba, Fan, Lixin, Cavanaugh, Quinn, Jiang, Minjie, Dai, Lisheng, Yang, Acong, Shao, Tie-Juan, Shapiro, Bruce A., Wang, Yun-Xing, Gu, Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369706/
https://www.ncbi.nlm.nih.gov/pubmed/30625327
http://dx.doi.org/10.1016/j.celrep.2018.12.054

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