Spy vs. spy: selecting the best reporter for (19)F NMR competition experiments

Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive (19)F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.

Detalles Bibliográficos
Autores principales: de Castro, Guilherme Vieira, Ciulli, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369734/
https://www.ncbi.nlm.nih.gov/pubmed/30644956
http://dx.doi.org/10.1039/c8cc09790a
Descripción
Sumario:Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive (19)F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.

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