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Spy vs. spy: selecting the best reporter for (19)F NMR competition experiments
Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive (19)F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369734/ https://www.ncbi.nlm.nih.gov/pubmed/30644956 http://dx.doi.org/10.1039/c8cc09790a |
| _version_ | 1783394244604461056 |
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| author | de Castro, Guilherme Vieira Ciulli, Alessio |
| author_facet | de Castro, Guilherme Vieira Ciulli, Alessio |
| author_sort | de Castro, Guilherme Vieira |
| collection | PubMed |
| description | Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive (19)F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption. |
| format | Online Article Text |
| id | pubmed-6369734 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Royal Society of Chemistry |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-63697342019-03-06 Spy vs. spy: selecting the best reporter for (19)F NMR competition experiments de Castro, Guilherme Vieira Ciulli, Alessio Chem Commun (Camb) Chemistry Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive (19)F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption. Royal Society of Chemistry 2019-02-04 2019-01-15 /pmc/articles/PMC6369734/ /pubmed/30644956 http://dx.doi.org/10.1039/c8cc09790a Text en This journal is © The Royal Society of Chemistry 2019 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0) |
| spellingShingle | Chemistry de Castro, Guilherme Vieira Ciulli, Alessio Spy vs. spy: selecting the best reporter for (19)F NMR competition experiments |
| title | Spy vs. spy: selecting the best reporter for (19)F NMR competition experiments
|
| title_full | Spy vs. spy: selecting the best reporter for (19)F NMR competition experiments
|
| title_fullStr | Spy vs. spy: selecting the best reporter for (19)F NMR competition experiments
|
| title_full_unstemmed | Spy vs. spy: selecting the best reporter for (19)F NMR competition experiments
|
| title_short | Spy vs. spy: selecting the best reporter for (19)F NMR competition experiments
|
| title_sort | spy vs. spy: selecting the best reporter for (19)f nmr competition experiments |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369734/ https://www.ncbi.nlm.nih.gov/pubmed/30644956 http://dx.doi.org/10.1039/c8cc09790a |
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