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Spy vs. spy: selecting the best reporter for (19)F NMR competition experiments
Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive (19)F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369734/ https://www.ncbi.nlm.nih.gov/pubmed/30644956 http://dx.doi.org/10.1039/c8cc09790a |