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Small molecule ISRIB suppresses the integrated stress response within a defined window of activation

Activation of the integrated stress response (ISR) by a variety of stresses triggers phosphorylation of the α-subunit of translation initiation factor eIF2. P-eIF2α inhibits eIF2B, the guanine nucleotide exchange factor that recycles inactive eIF2•GDP to active eIF2•GTP. eIF2 phosphorylation thereby...

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Detalles Bibliográficos
Autores principales:	Rabouw, Huib H., Langereis, Martijn A., Anand, Aditya A., Visser, Linda J., de Groot, Raoul J., Walter, Peter, van Kuppeveld, Frank J. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369741/ https://www.ncbi.nlm.nih.gov/pubmed/30674674 http://dx.doi.org/10.1073/pnas.1815767116

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