Cytotoxic CD8(+) T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons

Adaptive immune response is part of the dynamic changes that accompany motoneuron loss in amyotrophic lateral sclerosis (ALS). CD4(+) T cells that regulate a protective immunity during the neurodegenerative process have received the most attention. CD8(+) T cells are also observed in the spinal cord...

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Detalles Bibliográficos
Autores principales: Coque, Emmanuelle, Salsac, Céline, Espinosa-Carrasco, Gabriel, Varga, Béla, Degauque, Nicolas, Cadoux, Marion, Crabé, Roxane, Virenque, Anaïs, Soulard, Claire, Fierle, Julie K., Brodovitch, Alexandre, Libralato, Margot, Végh, Attila G., Venteo, Stéphanie, Scamps, Frédérique, Boucraut, José, Laplaud, David, Hernandez, Javier, Gergely, Csilla, Vincent, Thierry, Raoul, Cédric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369778/
https://www.ncbi.nlm.nih.gov/pubmed/30674678
http://dx.doi.org/10.1073/pnas.1815961116

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