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Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer
Colorectal cancer is the abnormal growth of cells in colon or rectum. Recent findings have acknowledged the role of bacterial infection and chronic inflammation in colorectal cancer initiation and progression. In order to detect and treat precancerous lesions, new tools are required, which may help...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369841/ https://www.ncbi.nlm.nih.gov/pubmed/30799920 http://dx.doi.org/10.2147/IJN.S188887 |
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author | Singh, Raminder Dumlupinar, Gokhan Andersson-Engels, Stefan Melgar, Silvia |
author_facet | Singh, Raminder Dumlupinar, Gokhan Andersson-Engels, Stefan Melgar, Silvia |
author_sort | Singh, Raminder |
collection | PubMed |
description | Colorectal cancer is the abnormal growth of cells in colon or rectum. Recent findings have acknowledged the role of bacterial infection and chronic inflammation in colorectal cancer initiation and progression. In order to detect and treat precancerous lesions, new tools are required, which may help to prevent or identify colorectal cancer at an early stage. To date, several different screening tests are available, including endoscopy, stool-based blood tests, and radiology-based tests. However, these analyses either lack sensitivity or are of an invasive nature. The use of fluorescently labeled probes can increase the detection sensitivity. However, autofluorescence, photobleaching, and photodamage are commonly encountered problems with fluorescence imaging. Upconverting nanoparticles (UCNPs) are recently developed lanthanide-doped nanocrystals that can be used as light-triggered luminescent probes and in drug delivery systems. In this review, we comprehensively summarize the recent developments and address future prospects of UCNP-based applications for diagnostics and therapeutic approaches associated with intestinal infection and colorectal cancer. |
format | Online Article Text |
id | pubmed-6369841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-63698412019-02-22 Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer Singh, Raminder Dumlupinar, Gokhan Andersson-Engels, Stefan Melgar, Silvia Int J Nanomedicine Review Colorectal cancer is the abnormal growth of cells in colon or rectum. Recent findings have acknowledged the role of bacterial infection and chronic inflammation in colorectal cancer initiation and progression. In order to detect and treat precancerous lesions, new tools are required, which may help to prevent or identify colorectal cancer at an early stage. To date, several different screening tests are available, including endoscopy, stool-based blood tests, and radiology-based tests. However, these analyses either lack sensitivity or are of an invasive nature. The use of fluorescently labeled probes can increase the detection sensitivity. However, autofluorescence, photobleaching, and photodamage are commonly encountered problems with fluorescence imaging. Upconverting nanoparticles (UCNPs) are recently developed lanthanide-doped nanocrystals that can be used as light-triggered luminescent probes and in drug delivery systems. In this review, we comprehensively summarize the recent developments and address future prospects of UCNP-based applications for diagnostics and therapeutic approaches associated with intestinal infection and colorectal cancer. Dove Medical Press 2019-02-07 /pmc/articles/PMC6369841/ /pubmed/30799920 http://dx.doi.org/10.2147/IJN.S188887 Text en © 2019 Singh et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Singh, Raminder Dumlupinar, Gokhan Andersson-Engels, Stefan Melgar, Silvia Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer |
title | Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer |
title_full | Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer |
title_fullStr | Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer |
title_full_unstemmed | Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer |
title_short | Emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer |
title_sort | emerging applications of upconverting nanoparticles in intestinal infection and colorectal cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369841/ https://www.ncbi.nlm.nih.gov/pubmed/30799920 http://dx.doi.org/10.2147/IJN.S188887 |
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