Molecular Modeling and Functional Analysis of Exome Sequencing–Derived Variants of Unknown Significance Identify a Novel, Constitutively Active FGFR2 Mutant in Cholangiocarcinoma

PURPOSE: Genomic testing has increased the quantity of information available to oncologists. Unfortunately, many identified sequence alterations are variants of unknown significance (VUSs), which thus limit the clinician’s ability to use these findings to inform treatment. We applied a combination o...

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Autores principales: Egan, Jan B., Marks, David L., Hogenson, Tara L., Vrabel, Anne M., Sigafoos, Ashley N., Tolosa, Ezequiel J., Carr, Ryan M., Safgren, Stephanie L., Enriquez Hesles, Elisa, Almada, Luciana L., Romecin-Duran, Paola A., Iguchi, Eriko, Ala’Aldeen, Aryan, Kocher, Jean-Pierre A., Oliver, Gavin R., Prodduturi, Naresh, Mead, David W., Hossain, Asif, Huneke, Norine E., Tagtow, Colleen M., Ailawadhi, Sikander, Ansell, Stephen M., Banck, Michaela S., Bryce, Alan H., Carballido, Estrella M., Chanan-Khan, Asher A., Curtis, Kelly K., Resnik, Ernesto, Gawryletz, Chelsea D., Go, Ronald S., Halfdanarson, Thorvardur R., Ho, Thai H., Joseph, Richard W., Kapoor, Prashant, Mansfield, Aaron S., Meurice, Nathalie, Nageswara Rao, Amulya A., Nowakowski, Grzegorz S., Pardanani, Animesh, Parikh, Sameer A., Cheville, John C., Feldman, Andrew L., Ramanathan, Ramesh K., Robinson, Steven I., Tibes, Raoul, Finnes, Heidi D., McCormick, Jennifer B., McWilliams, Robert R., Jatoi, Aminah, Patnaik, Mrinal M., Silva, Alvin C., Wieben, Eric D., McAllister, Tammy M., Rumilla, Kandelaria M., Kerr, Sarah E., Lazaridis, Konstantinos N., Farrugia, Gianrico, Stewart, A. Keith, Clark, Karl J., Kennedy, Eileen J., Klee, Eric W., Borad, Mitesh J., Fernandez-Zapico, Martin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Clinical Oncology 2017
Materias:
Original Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369924/
https://www.ncbi.nlm.nih.gov/pubmed/30761385
http://dx.doi.org/10.1200/PO.17.00018

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