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Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

The proteasome is an ATP-dependent, 2.5-megadalton machine responsible for selective protein degradation in eukaryotic cells. Here we present cryo-EM structures of the substrate-engaged human proteasome in seven conformational states at 2.8-3.6 Å resolution, captured during breakdown of a polyubiqui...

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Detalles Bibliográficos
Autores principales:	Dong, Yuanchen, Zhang, Shuwen, Wu, Zhaolong, Li, Xuemei, Wang, Wei Li, Zhu, Yanan, Stoilova-McPhie, Svetla, Lu, Ying, Finley, Daniel, Mao, Youdong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370054/ https://www.ncbi.nlm.nih.gov/pubmed/30479383 http://dx.doi.org/10.1038/s41586-018-0736-4

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