GABA(A) receptor signalling mechanisms revealed by structural pharmacology

Type-A γ-aminobutyric receptors (GABA(A)Rs) are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines and general anaesthetics, are among the most successful drugs in clinical use and common substances of abuse. Without reliable structural...

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Detalles Bibliográficos
Autores principales: Masiulis, Simonas, Desai, Rooma, Uchański, Tomasz, Martin, Itziar Serna, Laverty, Duncan, Karia, Dimple, Malinauskas, Tomas, Zivanov, Jasenko, Pardon, Els, Kotecha, Abhay, Steyaert, Jan, Miller, Keith W., Aricescu, A. Radu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370056/
https://www.ncbi.nlm.nih.gov/pubmed/30602790
http://dx.doi.org/10.1038/s41586-018-0832-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370056/
https://www.ncbi.nlm.nih.gov/pubmed/30602790
http://dx.doi.org/10.1038/s41586-018-0832-5

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