Cargando…
The efficacy of local liposomal bupivacaine infiltration on pain and recovery after Total Joint Arthroplasty: A systematic review and meta-analysis of randomized controlled trials
BACKGROUND: Total Joint Arthroplasty (TJA) is gradually emerging as the treatment of choice for end-stage osteoarthritis. In the past, Perioperative liposomal bupivacaine treatment is still a controversial subject in TJA. Therefore, we write this systematic review and meta-analysis to evaluate the e...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370122/ https://www.ncbi.nlm.nih.gov/pubmed/30653126 http://dx.doi.org/10.1097/MD.0000000000014092 |
_version_ | 1783394302406164480 |
---|---|
author | Zhao, Baocheng Ma, Xinlong Zhang, Jinli Ma, Jianxiong Cao, Qing |
author_facet | Zhao, Baocheng Ma, Xinlong Zhang, Jinli Ma, Jianxiong Cao, Qing |
author_sort | Zhao, Baocheng |
collection | PubMed |
description | BACKGROUND: Total Joint Arthroplasty (TJA) is gradually emerging as the treatment of choice for end-stage osteoarthritis. In the past, Perioperative liposomal bupivacaine treatment is still a controversial subject in TJA. Therefore, we write this systematic review and meta-analysis to evaluate the efficacy of liposomal bupivacaine on pain and recovery after TJA. MATERIALS AND METHODS: Embase, Pubmed, and Cochrane Library were comprehensively searched. Randomized controlled trials (RCTs), cohort studies were included in our meta-analysis. Twelve studies that compared liposomal bupivacaine groups with placebo groups were included in our meta-analysis. The research was reported according to the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. RCTs were included in our meta-analysis. RESULTS: Our study demonstrated that liposomal bupivacaine group was as effective as the placebo group in term of VAS score at 24 h (P = .09), 48 h (P = .97); Postoperative nausea (P = .72); and LOS (0.27). There was significant difference in terms of total morphine consumption at 24 h (P < .0001), 48 h (P = .0008). CONCLUSION: Our meta-analysis demonstrated that liposomal bupivacaine has similar pain control and functional recovery after TJA which compared with the control group. However, we still need large sample size, high-quality studies to explore the relationship between complications and dose response to give the final conclusion. |
format | Online Article Text |
id | pubmed-6370122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-63701222019-02-22 The efficacy of local liposomal bupivacaine infiltration on pain and recovery after Total Joint Arthroplasty: A systematic review and meta-analysis of randomized controlled trials Zhao, Baocheng Ma, Xinlong Zhang, Jinli Ma, Jianxiong Cao, Qing Medicine (Baltimore) Research Article BACKGROUND: Total Joint Arthroplasty (TJA) is gradually emerging as the treatment of choice for end-stage osteoarthritis. In the past, Perioperative liposomal bupivacaine treatment is still a controversial subject in TJA. Therefore, we write this systematic review and meta-analysis to evaluate the efficacy of liposomal bupivacaine on pain and recovery after TJA. MATERIALS AND METHODS: Embase, Pubmed, and Cochrane Library were comprehensively searched. Randomized controlled trials (RCTs), cohort studies were included in our meta-analysis. Twelve studies that compared liposomal bupivacaine groups with placebo groups were included in our meta-analysis. The research was reported according to the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. RCTs were included in our meta-analysis. RESULTS: Our study demonstrated that liposomal bupivacaine group was as effective as the placebo group in term of VAS score at 24 h (P = .09), 48 h (P = .97); Postoperative nausea (P = .72); and LOS (0.27). There was significant difference in terms of total morphine consumption at 24 h (P < .0001), 48 h (P = .0008). CONCLUSION: Our meta-analysis demonstrated that liposomal bupivacaine has similar pain control and functional recovery after TJA which compared with the control group. However, we still need large sample size, high-quality studies to explore the relationship between complications and dose response to give the final conclusion. Wolters Kluwer Health 2019-01-18 /pmc/articles/PMC6370122/ /pubmed/30653126 http://dx.doi.org/10.1097/MD.0000000000014092 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Zhao, Baocheng Ma, Xinlong Zhang, Jinli Ma, Jianxiong Cao, Qing The efficacy of local liposomal bupivacaine infiltration on pain and recovery after Total Joint Arthroplasty: A systematic review and meta-analysis of randomized controlled trials |
title | The efficacy of local liposomal bupivacaine infiltration on pain and recovery after Total Joint Arthroplasty: A systematic review and meta-analysis of randomized controlled trials |
title_full | The efficacy of local liposomal bupivacaine infiltration on pain and recovery after Total Joint Arthroplasty: A systematic review and meta-analysis of randomized controlled trials |
title_fullStr | The efficacy of local liposomal bupivacaine infiltration on pain and recovery after Total Joint Arthroplasty: A systematic review and meta-analysis of randomized controlled trials |
title_full_unstemmed | The efficacy of local liposomal bupivacaine infiltration on pain and recovery after Total Joint Arthroplasty: A systematic review and meta-analysis of randomized controlled trials |
title_short | The efficacy of local liposomal bupivacaine infiltration on pain and recovery after Total Joint Arthroplasty: A systematic review and meta-analysis of randomized controlled trials |
title_sort | efficacy of local liposomal bupivacaine infiltration on pain and recovery after total joint arthroplasty: a systematic review and meta-analysis of randomized controlled trials |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370122/ https://www.ncbi.nlm.nih.gov/pubmed/30653126 http://dx.doi.org/10.1097/MD.0000000000014092 |
work_keys_str_mv | AT zhaobaocheng theefficacyoflocalliposomalbupivacaineinfiltrationonpainandrecoveryaftertotaljointarthroplastyasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT maxinlong theefficacyoflocalliposomalbupivacaineinfiltrationonpainandrecoveryaftertotaljointarthroplastyasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT zhangjinli theefficacyoflocalliposomalbupivacaineinfiltrationonpainandrecoveryaftertotaljointarthroplastyasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT majianxiong theefficacyoflocalliposomalbupivacaineinfiltrationonpainandrecoveryaftertotaljointarthroplastyasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT caoqing theefficacyoflocalliposomalbupivacaineinfiltrationonpainandrecoveryaftertotaljointarthroplastyasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT zhaobaocheng efficacyoflocalliposomalbupivacaineinfiltrationonpainandrecoveryaftertotaljointarthroplastyasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT maxinlong efficacyoflocalliposomalbupivacaineinfiltrationonpainandrecoveryaftertotaljointarthroplastyasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT zhangjinli efficacyoflocalliposomalbupivacaineinfiltrationonpainandrecoveryaftertotaljointarthroplastyasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT majianxiong efficacyoflocalliposomalbupivacaineinfiltrationonpainandrecoveryaftertotaljointarthroplastyasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT caoqing efficacyoflocalliposomalbupivacaineinfiltrationonpainandrecoveryaftertotaljointarthroplastyasystematicreviewandmetaanalysisofrandomizedcontrolledtrials |