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The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch–Schonlein purpura: A PRISMA-compliant meta-analysis

BACKGROUND: To date, the relationship of Th17 and Treg cells to Henoch–Schonlein purpura (HSP) in children remains controversial. Therefore, a systematic review and meta-analysis was conducted to reveal the potential role of the Th17 and Treg cells in children in acute stage of HSP. METHODS: PubMed,...

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Autores principales: Li, Bowen, Ren, Qian, Ling, Jizu, Tao, Zhongbin, Yang, Xuemei, Li, Yuning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370168/
https://www.ncbi.nlm.nih.gov/pubmed/30653104
http://dx.doi.org/10.1097/MD.0000000000013991
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author Li, Bowen
Ren, Qian
Ling, Jizu
Tao, Zhongbin
Yang, Xuemei
Li, Yuning
author_facet Li, Bowen
Ren, Qian
Ling, Jizu
Tao, Zhongbin
Yang, Xuemei
Li, Yuning
author_sort Li, Bowen
collection PubMed
description BACKGROUND: To date, the relationship of Th17 and Treg cells to Henoch–Schonlein purpura (HSP) in children remains controversial. Therefore, a systematic review and meta-analysis was conducted to reveal the potential role of the Th17 and Treg cells in children in acute stage of HSP. METHODS: PubMed, Embase, Web of Science and China National Knowledge Internet (CNKI) were systematically searched for eligible studies up to November 03, 2017. Quality assessment was carried out according to the modification of the Newcastle-Ottawa Scale (NOS). The data were analyzed by Stata SE12.0 (StataCorp, College Station, TX). Standard mean difference (SMD) with 95% confidence intervals (CI) was calculated continuous data. RESULTS: A total of 25 eligible studies were identified after a thorough literature search. The pooled results of the meta-analysis showed that values of Th17 frequency (SMD = 2.60; 95% CI: 1.98 to 3.23; P < .0001; I(2) = 90.3%, P < .0001) and IL-17 level (SMD = 3.53; 95% CI: 2.71 to 4.35; P < .0001; I(2) = 95.6%, P < .001) were significantly higher in children with HSP as compared to healthy children. In contrast, our analysis showed significant lower values of Treg frequency (SMD = -2.86; 95% CI: -3.53 to -2.19; P < .001; I(2) = 92.4%, P < .001). However, no significance of IL-10 level was observed between children with HSP and healthy children (SMD = -1.22; 95% CI: -2.78 to 0.33; P < .01; I(2) = 95.9%, P < .001). CONCLUSION: In conclusion, our meta-analysis indicated that increased frequency of Th17 cells and level of IL-17, but lower frequency of Treg cells are associated with HSP in childhood. Considering the limitations of this meta-analysis, large-scaled studies need to be conducted to validate the current results.
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spelling pubmed-63701682019-02-22 The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch–Schonlein purpura: A PRISMA-compliant meta-analysis Li, Bowen Ren, Qian Ling, Jizu Tao, Zhongbin Yang, Xuemei Li, Yuning Medicine (Baltimore) Research Article BACKGROUND: To date, the relationship of Th17 and Treg cells to Henoch–Schonlein purpura (HSP) in children remains controversial. Therefore, a systematic review and meta-analysis was conducted to reveal the potential role of the Th17 and Treg cells in children in acute stage of HSP. METHODS: PubMed, Embase, Web of Science and China National Knowledge Internet (CNKI) were systematically searched for eligible studies up to November 03, 2017. Quality assessment was carried out according to the modification of the Newcastle-Ottawa Scale (NOS). The data were analyzed by Stata SE12.0 (StataCorp, College Station, TX). Standard mean difference (SMD) with 95% confidence intervals (CI) was calculated continuous data. RESULTS: A total of 25 eligible studies were identified after a thorough literature search. The pooled results of the meta-analysis showed that values of Th17 frequency (SMD = 2.60; 95% CI: 1.98 to 3.23; P < .0001; I(2) = 90.3%, P < .0001) and IL-17 level (SMD = 3.53; 95% CI: 2.71 to 4.35; P < .0001; I(2) = 95.6%, P < .001) were significantly higher in children with HSP as compared to healthy children. In contrast, our analysis showed significant lower values of Treg frequency (SMD = -2.86; 95% CI: -3.53 to -2.19; P < .001; I(2) = 92.4%, P < .001). However, no significance of IL-10 level was observed between children with HSP and healthy children (SMD = -1.22; 95% CI: -2.78 to 0.33; P < .01; I(2) = 95.9%, P < .001). CONCLUSION: In conclusion, our meta-analysis indicated that increased frequency of Th17 cells and level of IL-17, but lower frequency of Treg cells are associated with HSP in childhood. Considering the limitations of this meta-analysis, large-scaled studies need to be conducted to validate the current results. Wolters Kluwer Health 2019-01-18 /pmc/articles/PMC6370168/ /pubmed/30653104 http://dx.doi.org/10.1097/MD.0000000000013991 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Li, Bowen
Ren, Qian
Ling, Jizu
Tao, Zhongbin
Yang, Xuemei
Li, Yuning
The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch–Schonlein purpura: A PRISMA-compliant meta-analysis
title The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch–Schonlein purpura: A PRISMA-compliant meta-analysis
title_full The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch–Schonlein purpura: A PRISMA-compliant meta-analysis
title_fullStr The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch–Schonlein purpura: A PRISMA-compliant meta-analysis
title_full_unstemmed The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch–Schonlein purpura: A PRISMA-compliant meta-analysis
title_short The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch–Schonlein purpura: A PRISMA-compliant meta-analysis
title_sort change of th17/treg cells and il-10/il-17 in chinese children with henoch–schonlein purpura: a prisma-compliant meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370168/
https://www.ncbi.nlm.nih.gov/pubmed/30653104
http://dx.doi.org/10.1097/MD.0000000000013991
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