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The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch–Schonlein purpura: A PRISMA-compliant meta-analysis
BACKGROUND: To date, the relationship of Th17 and Treg cells to Henoch–Schonlein purpura (HSP) in children remains controversial. Therefore, a systematic review and meta-analysis was conducted to reveal the potential role of the Th17 and Treg cells in children in acute stage of HSP. METHODS: PubMed,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370168/ https://www.ncbi.nlm.nih.gov/pubmed/30653104 http://dx.doi.org/10.1097/MD.0000000000013991 |
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author | Li, Bowen Ren, Qian Ling, Jizu Tao, Zhongbin Yang, Xuemei Li, Yuning |
author_facet | Li, Bowen Ren, Qian Ling, Jizu Tao, Zhongbin Yang, Xuemei Li, Yuning |
author_sort | Li, Bowen |
collection | PubMed |
description | BACKGROUND: To date, the relationship of Th17 and Treg cells to Henoch–Schonlein purpura (HSP) in children remains controversial. Therefore, a systematic review and meta-analysis was conducted to reveal the potential role of the Th17 and Treg cells in children in acute stage of HSP. METHODS: PubMed, Embase, Web of Science and China National Knowledge Internet (CNKI) were systematically searched for eligible studies up to November 03, 2017. Quality assessment was carried out according to the modification of the Newcastle-Ottawa Scale (NOS). The data were analyzed by Stata SE12.0 (StataCorp, College Station, TX). Standard mean difference (SMD) with 95% confidence intervals (CI) was calculated continuous data. RESULTS: A total of 25 eligible studies were identified after a thorough literature search. The pooled results of the meta-analysis showed that values of Th17 frequency (SMD = 2.60; 95% CI: 1.98 to 3.23; P < .0001; I(2) = 90.3%, P < .0001) and IL-17 level (SMD = 3.53; 95% CI: 2.71 to 4.35; P < .0001; I(2) = 95.6%, P < .001) were significantly higher in children with HSP as compared to healthy children. In contrast, our analysis showed significant lower values of Treg frequency (SMD = -2.86; 95% CI: -3.53 to -2.19; P < .001; I(2) = 92.4%, P < .001). However, no significance of IL-10 level was observed between children with HSP and healthy children (SMD = -1.22; 95% CI: -2.78 to 0.33; P < .01; I(2) = 95.9%, P < .001). CONCLUSION: In conclusion, our meta-analysis indicated that increased frequency of Th17 cells and level of IL-17, but lower frequency of Treg cells are associated with HSP in childhood. Considering the limitations of this meta-analysis, large-scaled studies need to be conducted to validate the current results. |
format | Online Article Text |
id | pubmed-6370168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-63701682019-02-22 The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch–Schonlein purpura: A PRISMA-compliant meta-analysis Li, Bowen Ren, Qian Ling, Jizu Tao, Zhongbin Yang, Xuemei Li, Yuning Medicine (Baltimore) Research Article BACKGROUND: To date, the relationship of Th17 and Treg cells to Henoch–Schonlein purpura (HSP) in children remains controversial. Therefore, a systematic review and meta-analysis was conducted to reveal the potential role of the Th17 and Treg cells in children in acute stage of HSP. METHODS: PubMed, Embase, Web of Science and China National Knowledge Internet (CNKI) were systematically searched for eligible studies up to November 03, 2017. Quality assessment was carried out according to the modification of the Newcastle-Ottawa Scale (NOS). The data were analyzed by Stata SE12.0 (StataCorp, College Station, TX). Standard mean difference (SMD) with 95% confidence intervals (CI) was calculated continuous data. RESULTS: A total of 25 eligible studies were identified after a thorough literature search. The pooled results of the meta-analysis showed that values of Th17 frequency (SMD = 2.60; 95% CI: 1.98 to 3.23; P < .0001; I(2) = 90.3%, P < .0001) and IL-17 level (SMD = 3.53; 95% CI: 2.71 to 4.35; P < .0001; I(2) = 95.6%, P < .001) were significantly higher in children with HSP as compared to healthy children. In contrast, our analysis showed significant lower values of Treg frequency (SMD = -2.86; 95% CI: -3.53 to -2.19; P < .001; I(2) = 92.4%, P < .001). However, no significance of IL-10 level was observed between children with HSP and healthy children (SMD = -1.22; 95% CI: -2.78 to 0.33; P < .01; I(2) = 95.9%, P < .001). CONCLUSION: In conclusion, our meta-analysis indicated that increased frequency of Th17 cells and level of IL-17, but lower frequency of Treg cells are associated with HSP in childhood. Considering the limitations of this meta-analysis, large-scaled studies need to be conducted to validate the current results. Wolters Kluwer Health 2019-01-18 /pmc/articles/PMC6370168/ /pubmed/30653104 http://dx.doi.org/10.1097/MD.0000000000013991 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Li, Bowen Ren, Qian Ling, Jizu Tao, Zhongbin Yang, Xuemei Li, Yuning The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch–Schonlein purpura: A PRISMA-compliant meta-analysis |
title | The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch–Schonlein purpura: A PRISMA-compliant meta-analysis |
title_full | The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch–Schonlein purpura: A PRISMA-compliant meta-analysis |
title_fullStr | The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch–Schonlein purpura: A PRISMA-compliant meta-analysis |
title_full_unstemmed | The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch–Schonlein purpura: A PRISMA-compliant meta-analysis |
title_short | The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch–Schonlein purpura: A PRISMA-compliant meta-analysis |
title_sort | change of th17/treg cells and il-10/il-17 in chinese children with henoch–schonlein purpura: a prisma-compliant meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370168/ https://www.ncbi.nlm.nih.gov/pubmed/30653104 http://dx.doi.org/10.1097/MD.0000000000013991 |
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