Inherent versus induced protein flexibility: Comparisons within and between apo and holo structures

Understanding how ligand binding influences protein flexibility is important, especially in rational drug design. Protein flexibility upon ligand binding is analyzed herein using 305 proteins with 2369 crystal structures with ligands (holo) and 1679 without (apo). Each protein has at least two apo a...

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Detalles Bibliográficos
Autores principales: Clark, Jordan J., Benson, Mark L., Smith, Richard D., Carlson, Heather A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370239/
https://www.ncbi.nlm.nih.gov/pubmed/30699115
http://dx.doi.org/10.1371/journal.pcbi.1006705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370239/
https://www.ncbi.nlm.nih.gov/pubmed/30699115
http://dx.doi.org/10.1371/journal.pcbi.1006705

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