Cargando…
Inherent versus induced protein flexibility: Comparisons within and between apo and holo structures
Understanding how ligand binding influences protein flexibility is important, especially in rational drug design. Protein flexibility upon ligand binding is analyzed herein using 305 proteins with 2369 crystal structures with ligands (holo) and 1679 without (apo). Each protein has at least two apo a...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370239/ https://www.ncbi.nlm.nih.gov/pubmed/30699115 http://dx.doi.org/10.1371/journal.pcbi.1006705 |