Melatonin decreases M1 polarization via attenuating mitochondrial oxidative damage depending on UCP2 pathway in prorenin-treated microglia

Accumulating evidence suggests that neuroinflammation and oxidative stress in cardiovascular center contribute to the pathological processes underlying hypertension. Microglia activation triggers the inflammation and oxidative stress. Melatonin is a documented potent anti-inflammatory regent and ant...

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Detalles Bibliográficos
Autores principales: Hu, Li, Zhang, Shutian, Wen, Haoyu, Liu, Tianfeng, Cai, Jian, Du, Dongshu, Zhu, Danian, Chen, Fuxue, Xia, Chunmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370243/
https://www.ncbi.nlm.nih.gov/pubmed/30742657
http://dx.doi.org/10.1371/journal.pone.0212138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370243/
https://www.ncbi.nlm.nih.gov/pubmed/30742657
http://dx.doi.org/10.1371/journal.pone.0212138

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