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Synthesis of hapten, generation of specific polyclonal antibody and development of ELISA with high sensitivity for therapeutic monitoring of crizotinib
Crizotinib (CZT) is a potent drug used for treatment of non-small cell lung cancer (NSCLC); however, its circulating concentration variability has been associated with acquired resistance and toxicity, restricting the success of cancer treatment. As such, the development of an assay that monitors CZ...
Autores principales: | Al-Shehri, Mona M., El-Azab, Adel S., El-Gendy, Manal A., Hamidaddin, Mohammed A., Darwish, Ibrahim A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370279/ https://www.ncbi.nlm.nih.gov/pubmed/30742664 http://dx.doi.org/10.1371/journal.pone.0212048 |
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