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A single-institution retrospective analysis of gastric carcinoma with positive peritoneal lavage cytology and without serosal invasion: A case series

BACKGROUND AND OBJECTIVES: Peritoneal dissemination of gastric cancer is often associated with serosal infiltration. The aim of this study was to evaluate the clinical importance of peritoneal lavage cytology in patients with gastric carcinoma without serosal invasion. The incidence and impact on pr...

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Autores principales: Sakata, Taizo, Takahata, Takaomi, Kimura, Toshikazu, Yasuhara, Isao, Kojima, Toru, Akazai, Yoshihiro, Mimura, Tetsushige, Lefor, Alan Kawarai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370578/
https://www.ncbi.nlm.nih.gov/pubmed/30792857
http://dx.doi.org/10.1016/j.amsu.2019.01.003
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author Sakata, Taizo
Takahata, Takaomi
Kimura, Toshikazu
Yasuhara, Isao
Kojima, Toru
Akazai, Yoshihiro
Mimura, Tetsushige
Lefor, Alan Kawarai
author_facet Sakata, Taizo
Takahata, Takaomi
Kimura, Toshikazu
Yasuhara, Isao
Kojima, Toru
Akazai, Yoshihiro
Mimura, Tetsushige
Lefor, Alan Kawarai
author_sort Sakata, Taizo
collection PubMed
description BACKGROUND AND OBJECTIVES: Peritoneal dissemination of gastric cancer is often associated with serosal infiltration. The aim of this study was to evaluate the clinical importance of peritoneal lavage cytology in patients with gastric carcinoma without serosal invasion. The incidence and impact on prognosis of positive cytology were analyzed. METHODS: Of 2768 patients with gastric cancer, outcomes and pathological characteristics of 973 patients were reviewed retrospectively. All patients underwent peritoneal lavage at laparotomy for curative or palliative resection of gastric cancer between 1999 and 2017. Among these, 479 who underwent surgery from January 1999 to March 2012 were also reviewed to analyze 5-year survival. RESULTS: Of 973 patients enrolled, 338 (35%) did not have serosal invasion, and peritoneal cytology was positive in 4/338 (1.2%). Of these four patients, one had submucosal invasion and three had muscularis propria invasion. Of 635 patients with serosal invasion, peritoneal cytology was positive in 74/635 (12%). Of 479 patients reviewed for survival, cytology was positive in 32/479, with 3/32 (9%) surviving for five years, and cytology was negative in 447 patients with 266/447 (60%) surviving for five years. CONCLUSIONS: Cytologic evaluation should be routinely performed in patients with early-stage gastric cancer.
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spelling pubmed-63705782019-02-21 A single-institution retrospective analysis of gastric carcinoma with positive peritoneal lavage cytology and without serosal invasion: A case series Sakata, Taizo Takahata, Takaomi Kimura, Toshikazu Yasuhara, Isao Kojima, Toru Akazai, Yoshihiro Mimura, Tetsushige Lefor, Alan Kawarai Ann Med Surg (Lond) Original Research BACKGROUND AND OBJECTIVES: Peritoneal dissemination of gastric cancer is often associated with serosal infiltration. The aim of this study was to evaluate the clinical importance of peritoneal lavage cytology in patients with gastric carcinoma without serosal invasion. The incidence and impact on prognosis of positive cytology were analyzed. METHODS: Of 2768 patients with gastric cancer, outcomes and pathological characteristics of 973 patients were reviewed retrospectively. All patients underwent peritoneal lavage at laparotomy for curative or palliative resection of gastric cancer between 1999 and 2017. Among these, 479 who underwent surgery from January 1999 to March 2012 were also reviewed to analyze 5-year survival. RESULTS: Of 973 patients enrolled, 338 (35%) did not have serosal invasion, and peritoneal cytology was positive in 4/338 (1.2%). Of these four patients, one had submucosal invasion and three had muscularis propria invasion. Of 635 patients with serosal invasion, peritoneal cytology was positive in 74/635 (12%). Of 479 patients reviewed for survival, cytology was positive in 32/479, with 3/32 (9%) surviving for five years, and cytology was negative in 447 patients with 266/447 (60%) surviving for five years. CONCLUSIONS: Cytologic evaluation should be routinely performed in patients with early-stage gastric cancer. Elsevier 2019-01-30 /pmc/articles/PMC6370578/ /pubmed/30792857 http://dx.doi.org/10.1016/j.amsu.2019.01.003 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Research
Sakata, Taizo
Takahata, Takaomi
Kimura, Toshikazu
Yasuhara, Isao
Kojima, Toru
Akazai, Yoshihiro
Mimura, Tetsushige
Lefor, Alan Kawarai
A single-institution retrospective analysis of gastric carcinoma with positive peritoneal lavage cytology and without serosal invasion: A case series
title A single-institution retrospective analysis of gastric carcinoma with positive peritoneal lavage cytology and without serosal invasion: A case series
title_full A single-institution retrospective analysis of gastric carcinoma with positive peritoneal lavage cytology and without serosal invasion: A case series
title_fullStr A single-institution retrospective analysis of gastric carcinoma with positive peritoneal lavage cytology and without serosal invasion: A case series
title_full_unstemmed A single-institution retrospective analysis of gastric carcinoma with positive peritoneal lavage cytology and without serosal invasion: A case series
title_short A single-institution retrospective analysis of gastric carcinoma with positive peritoneal lavage cytology and without serosal invasion: A case series
title_sort single-institution retrospective analysis of gastric carcinoma with positive peritoneal lavage cytology and without serosal invasion: a case series
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370578/
https://www.ncbi.nlm.nih.gov/pubmed/30792857
http://dx.doi.org/10.1016/j.amsu.2019.01.003
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