Predicting Directions of Changes in Genotype Proportions Between Norovirus Seasons in Japan

The norovirus forecasting system (NOROCAST) has been developed for predicting directions of changes in genotype proportions between human norovirus (HuNoV) seasons in Japan through modeling herd immunity to structural protein 1 (VP1). Here 404 nearly complete genomic sequences of HuNoV were analyzed...

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Autores principales: Suzuki, Yoshiyuki, Doan, Yen Hai, Kimura, Hirokazu, Shinomiya, Hiroto, Shirabe, Komei, Katayama, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370659/
https://www.ncbi.nlm.nih.gov/pubmed/30804908
http://dx.doi.org/10.3389/fmicb.2019.00116
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author Suzuki, Yoshiyuki
Doan, Yen Hai
Kimura, Hirokazu
Shinomiya, Hiroto
Shirabe, Komei
Katayama, Kazuhiko
author_facet Suzuki, Yoshiyuki
Doan, Yen Hai
Kimura, Hirokazu
Shinomiya, Hiroto
Shirabe, Komei
Katayama, Kazuhiko
author_sort Suzuki, Yoshiyuki
collection PubMed
description The norovirus forecasting system (NOROCAST) has been developed for predicting directions of changes in genotype proportions between human norovirus (HuNoV) seasons in Japan through modeling herd immunity to structural protein 1 (VP1). Here 404 nearly complete genomic sequences of HuNoV were analyzed to examine whether the performance of NOROCAST could be improved by modeling herd immunity to VP2 and non-structural proteins (NS) in addition to VP1. It was found that the applicability of NOROCAST may be extended by compensating for unavailable sequence data and observed genotype proportions of 0 in each season. Incorporation of herd immunity to VP2 and NS did not appear to improve the performance of NOROCAST, suggesting that VP1 may be a suitable target of vaccines.
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spelling pubmed-63706592019-02-25 Predicting Directions of Changes in Genotype Proportions Between Norovirus Seasons in Japan Suzuki, Yoshiyuki Doan, Yen Hai Kimura, Hirokazu Shinomiya, Hiroto Shirabe, Komei Katayama, Kazuhiko Front Microbiol Microbiology The norovirus forecasting system (NOROCAST) has been developed for predicting directions of changes in genotype proportions between human norovirus (HuNoV) seasons in Japan through modeling herd immunity to structural protein 1 (VP1). Here 404 nearly complete genomic sequences of HuNoV were analyzed to examine whether the performance of NOROCAST could be improved by modeling herd immunity to VP2 and non-structural proteins (NS) in addition to VP1. It was found that the applicability of NOROCAST may be extended by compensating for unavailable sequence data and observed genotype proportions of 0 in each season. Incorporation of herd immunity to VP2 and NS did not appear to improve the performance of NOROCAST, suggesting that VP1 may be a suitable target of vaccines. Frontiers Media S.A. 2019-02-05 /pmc/articles/PMC6370659/ /pubmed/30804908 http://dx.doi.org/10.3389/fmicb.2019.00116 Text en Copyright © 2019 Suzuki, Doan, Kimura, Shinomiya, Shirabe and Katayama. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Suzuki, Yoshiyuki
Doan, Yen Hai
Kimura, Hirokazu
Shinomiya, Hiroto
Shirabe, Komei
Katayama, Kazuhiko
Predicting Directions of Changes in Genotype Proportions Between Norovirus Seasons in Japan
title Predicting Directions of Changes in Genotype Proportions Between Norovirus Seasons in Japan
title_full Predicting Directions of Changes in Genotype Proportions Between Norovirus Seasons in Japan
title_fullStr Predicting Directions of Changes in Genotype Proportions Between Norovirus Seasons in Japan
title_full_unstemmed Predicting Directions of Changes in Genotype Proportions Between Norovirus Seasons in Japan
title_short Predicting Directions of Changes in Genotype Proportions Between Norovirus Seasons in Japan
title_sort predicting directions of changes in genotype proportions between norovirus seasons in japan
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370659/
https://www.ncbi.nlm.nih.gov/pubmed/30804908
http://dx.doi.org/10.3389/fmicb.2019.00116
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