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Deacetylation Inhibition Reverses PABPN1-Dependent Muscle Wasting

Reduced poly(A)-binding protein nuclear 1 (PABPN1) levels cause aging-associated muscle wasting. PABPN1 is a multifunctional regulator of mRNA processing. To elucidate the molecular mechanisms causing PABPN1-mediated muscle wasting, we compared the transcriptome with the proteome in mouse muscles ex...

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Detalles Bibliográficos
Autores principales:	Olie, Cyriel S., Riaz, Muhammad, Konietzny, Rebecca, Charles, Philip D., Pinto-Fernandez, Adan, Kiełbasa, Szymon M., Aartsma-Rus, A., Goeman, Jelle J., Kessler, Benedikt M., Raz, Vered
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370712/ https://www.ncbi.nlm.nih.gov/pubmed/30739015 http://dx.doi.org/10.1016/j.isci.2019.01.024

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