Cargando…
Association Between Parkinson's Disease and Atrial Fibrillation: A Population-Based Study
Introduction: Autonomic nervous system (ANS) dysfunction contributes to several non-motor symptoms of Parkinson's disease (PD). In addition, ANS plays a role in the genesis and maintenance of atrial fibrillation (AF). This study investigated the temporal association between PD and AF. Methods:...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370731/ https://www.ncbi.nlm.nih.gov/pubmed/30804869 http://dx.doi.org/10.3389/fneur.2019.00022 |
_version_ | 1783394409727918080 |
---|---|
author | Hong, Chien-Tai Chan, Lung Wu, Dean Chen, Wan-Ting Chien, Li-Nien |
author_facet | Hong, Chien-Tai Chan, Lung Wu, Dean Chen, Wan-Ting Chien, Li-Nien |
author_sort | Hong, Chien-Tai |
collection | PubMed |
description | Introduction: Autonomic nervous system (ANS) dysfunction contributes to several non-motor symptoms of Parkinson's disease (PD). In addition, ANS plays a role in the genesis and maintenance of atrial fibrillation (AF). This study investigated the temporal association between PD and AF. Methods: Data were obtained from the National Health Insurance Research Database of Taiwan. In total, 15,375 patients with newly diagnosed PD were matched with four controls each based on the propensity score. This study was bidirectional. A case-control study for the odds ratio (OR) of AF before PD and within 2 years of PD diagnosis was evaluated through conditional logistic regression. Furthermore, a cohort study on the subdistribution hazard ratio (SHR) for new-onset AF 2 years after PD diagnosis was evaluated using competing risk analysis. Results: In the case-control study, PD was found to be significantly comorbid with AF (adjusted OR: 1.15, 95% confidence interval [CI]: 1.04–1.28). Subgroup analysis demonstrated that this association consistently presented in the absence of confounding factors of AF. In the cohort study, people with PD were found to have a lower risk of AF (adjusted SHR: 0.92, 95% CI: 0.86–0.98). However, a consistent association was not observed between the confounding factors of AF and PD during the subgroup analysis. Conclusions: This study demonstrated that the premotor and early stages of PD were comorbid with AF, whereas the risk of AF was lower in the later stages. Thus, AF might be a premotor predictive biomarker and comorbidity of early PD. |
format | Online Article Text |
id | pubmed-6370731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63707312019-02-25 Association Between Parkinson's Disease and Atrial Fibrillation: A Population-Based Study Hong, Chien-Tai Chan, Lung Wu, Dean Chen, Wan-Ting Chien, Li-Nien Front Neurol Neurology Introduction: Autonomic nervous system (ANS) dysfunction contributes to several non-motor symptoms of Parkinson's disease (PD). In addition, ANS plays a role in the genesis and maintenance of atrial fibrillation (AF). This study investigated the temporal association between PD and AF. Methods: Data were obtained from the National Health Insurance Research Database of Taiwan. In total, 15,375 patients with newly diagnosed PD were matched with four controls each based on the propensity score. This study was bidirectional. A case-control study for the odds ratio (OR) of AF before PD and within 2 years of PD diagnosis was evaluated through conditional logistic regression. Furthermore, a cohort study on the subdistribution hazard ratio (SHR) for new-onset AF 2 years after PD diagnosis was evaluated using competing risk analysis. Results: In the case-control study, PD was found to be significantly comorbid with AF (adjusted OR: 1.15, 95% confidence interval [CI]: 1.04–1.28). Subgroup analysis demonstrated that this association consistently presented in the absence of confounding factors of AF. In the cohort study, people with PD were found to have a lower risk of AF (adjusted SHR: 0.92, 95% CI: 0.86–0.98). However, a consistent association was not observed between the confounding factors of AF and PD during the subgroup analysis. Conclusions: This study demonstrated that the premotor and early stages of PD were comorbid with AF, whereas the risk of AF was lower in the later stages. Thus, AF might be a premotor predictive biomarker and comorbidity of early PD. Frontiers Media S.A. 2019-02-05 /pmc/articles/PMC6370731/ /pubmed/30804869 http://dx.doi.org/10.3389/fneur.2019.00022 Text en Copyright © 2019 Hong, Chan, Wu, Chen and Chien. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Hong, Chien-Tai Chan, Lung Wu, Dean Chen, Wan-Ting Chien, Li-Nien Association Between Parkinson's Disease and Atrial Fibrillation: A Population-Based Study |
title | Association Between Parkinson's Disease and Atrial Fibrillation: A Population-Based Study |
title_full | Association Between Parkinson's Disease and Atrial Fibrillation: A Population-Based Study |
title_fullStr | Association Between Parkinson's Disease and Atrial Fibrillation: A Population-Based Study |
title_full_unstemmed | Association Between Parkinson's Disease and Atrial Fibrillation: A Population-Based Study |
title_short | Association Between Parkinson's Disease and Atrial Fibrillation: A Population-Based Study |
title_sort | association between parkinson's disease and atrial fibrillation: a population-based study |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370731/ https://www.ncbi.nlm.nih.gov/pubmed/30804869 http://dx.doi.org/10.3389/fneur.2019.00022 |
work_keys_str_mv | AT hongchientai associationbetweenparkinsonsdiseaseandatrialfibrillationapopulationbasedstudy AT chanlung associationbetweenparkinsonsdiseaseandatrialfibrillationapopulationbasedstudy AT wudean associationbetweenparkinsonsdiseaseandatrialfibrillationapopulationbasedstudy AT chenwanting associationbetweenparkinsonsdiseaseandatrialfibrillationapopulationbasedstudy AT chienlinien associationbetweenparkinsonsdiseaseandatrialfibrillationapopulationbasedstudy |