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Early Stage Alpha-Synuclein Amyloid Fibrils are Reservoirs of Membrane-Binding Species

The presence of αSN fibrils indisputably associates with the development of synucleinopathies. However, while certain fibril morphologies have been linked to downstream pathological phenotypes, others appear less harmful, leading to the concept of fibril strains, originally described in relation to...

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Detalles Bibliográficos
Autores principales: Skamris, Thomas, Marasini, Carlotta, Madsen, Kenneth L., Foderà, Vito, Vestergaard, Bente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370759/
https://www.ncbi.nlm.nih.gov/pubmed/30741994
http://dx.doi.org/10.1038/s41598-018-38271-2