Constitutive IP(3) signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP(3) receptor disruptor BIRD-2

Anti-apoptotic Bcl-2 proteins are upregulated in different cancers, including diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL), enabling survival by inhibiting pro-apoptotic Bcl-2-family members and inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R)-mediated Ca(2+)-si...

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Detalles Bibliográficos
Autores principales: Bittremieux, Mart, La Rovere, Rita M., Akl, Haidar, Martines, Claudio, Welkenhuyzen, Kirsten, Dubron, Kathia, Baes, Myriam, Janssens, Ann, Vandenberghe, Peter, Laurenti, Luca, Rietdorf, Katja, Morciano, Giampaolo, Pinton, Paolo, Mikoshiba, Katsuhiko, Bootman, Martin D., Efremov, Dimitar G., De Smedt, Humbert, Parys, Jan B., Bultynck, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370760/
https://www.ncbi.nlm.nih.gov/pubmed/29899382
http://dx.doi.org/10.1038/s41418-018-0142-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370760/
https://www.ncbi.nlm.nih.gov/pubmed/29899382
http://dx.doi.org/10.1038/s41418-018-0142-3

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