Reversible fold-switching controls the functional cycle of the antitermination factor RfaH

RfaH, member of the NusG/Spt5 family, activates virulence genes in Gram-negative pathogens. RfaH exists in two states, with its C-terminal domain (CTD) folded either as α-helical hairpin or β-barrel. In free RfaH, the α-helical CTD interacts with, and masks the RNA polymerase binding site on, the N-...

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Detalles Bibliográficos
Autores principales: Zuber, Philipp Konrad, Schweimer, Kristian, Rösch, Paul, Artsimovitch, Irina, Knauer, Stefan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370827/
https://www.ncbi.nlm.nih.gov/pubmed/30742024
http://dx.doi.org/10.1038/s41467-019-08567-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370827/
https://www.ncbi.nlm.nih.gov/pubmed/30742024
http://dx.doi.org/10.1038/s41467-019-08567-6

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