Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation

Polyubiquitination promotes proteasomal degradation, or signaling and localization, of targeted proteins. Here we show that the E3 ubiquitin ligase Hectd3 is necessary for pathogenic Th17 cell generation in experimental autoimmune encephalomyelitis (EAE), a mouse model for human multiple sclerosis....

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Detalles Bibliográficos
Autores principales: Cho, Jonathan J., Xu, Zhiwei, Parthasarathy, Upasana, Drashansky, Theodore T., Helm, Eric Y., Zuniga, Ashley N., Lorentsen, Kyle J., Mansouri, Samira, Cho, Joshua Y., Edelmann, Mariola J., Duong, Duc M., Gehring, Torben, Seeholzer, Thomas, Krappmann, Daniel, Uddin, Mohammad N., Califano, Danielle, Wang, Rejean L., Jin, Lei, Li, Hongmin, Lv, Dongwen, Zhou, Daohong, Zhou, Liang, Avram, Dorina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370850/
https://www.ncbi.nlm.nih.gov/pubmed/30741923
http://dx.doi.org/10.1038/s41467-019-08605-3

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