Cargando…
A phenome-wide association study to discover pleiotropic effects of PCSK9, APOB, and LDLR
We conducted an electronic health record (EHR)-based phenome-wide association study (PheWAS) to discover pleiotropic effects of variants in three lipoprotein metabolism genes PCSK9, APOB, and LDLR. Using high-density genotype data, we tested the associations of variants in the three genes with 1232...
Autores principales: | Safarova, Maya S., Satterfield, Benjamin A., Fan, Xiao, Austin, Erin E., Ye, Zhan, Bastarache, Lisa, Zheng, Neil, Ritchie, Marylyn D., Borthwick, Kenneth M., Williams, Marc S., Larson, Eric B., Scrol, Aaron, Jarvik, Gail P., Crosslin, David R., Leppig, Kathleen, Rasmussen-Torvik, Laura J., Pendergrass, Sarah A., Sturm, Amy C., Namjou, Bahram, Shah, Amy Sanghavi, Carroll, Robert J., Chung, Wendy K., Wei, Wei-Qi, Feng, QiPing, Stein, C. Michael, Roden, Dan M., Manolio, Teri A., Schaid, Daniel J., Denny, Joshua C., Hebbring, Scott J., de Andrade, Mariza, Kullo, Iftikhar J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370860/ https://www.ncbi.nlm.nih.gov/pubmed/30774981 http://dx.doi.org/10.1038/s41525-019-0078-7 |
Ejemplares similares
-
Detecting potential pleiotropy across cardiovascular and neurological diseases using univariate, bivariate, and
multivariate methods on 43,870 individuals from the eMERGE network
por: Zhang, Xinyuan, et al.
Publicado: (2019) -
Association between triglycerides, known risk SNVs and conserved rare variation in SLC25A40 in a multi-ancestry cohort
por: Rosenthal, Elisabeth A., et al.
Publicado: (2021) -
Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders
por: Zhang, Xinyuan, et al.
Publicado: (2022) -
eMERGE Phenome-Wide Association Study (PheWAS) identifies clinical associations and pleiotropy for stop-gain variants
por: Verma, Anurag, et al.
Publicado: (2016) -
Building a family network from genetic testing
por: Leppig, Kathleen A., et al.
Publicado: (2016)