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Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives

OBJECTIVES: So far, few studies have investigated cortical thickness (CT) and surface area (SA) measures in bipolar disorder type I (BDI) in comparison to a high genetic risk group such as first-degree relatives (FR). This study aimed to examine CT and SA differences between BDI, FR and healthy cont...

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Autores principales: Yalin, Nefize, Saricicek, Aybala, Hidiroglu, Ceren, Zugman, Andre, Direk, Nese, Ada, Emel, Cavusoglu, Berrin, Er, Ayşe, Isik, Gizem, Ceylan, Deniz, Tunca, Zeliha, Kempton, Matthew J., Ozerdem, Aysegul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370861/
https://www.ncbi.nlm.nih.gov/pubmed/30738374
http://dx.doi.org/10.1016/j.nicl.2019.101695
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author Yalin, Nefize
Saricicek, Aybala
Hidiroglu, Ceren
Zugman, Andre
Direk, Nese
Ada, Emel
Cavusoglu, Berrin
Er, Ayşe
Isik, Gizem
Ceylan, Deniz
Tunca, Zeliha
Kempton, Matthew J.
Ozerdem, Aysegul
author_facet Yalin, Nefize
Saricicek, Aybala
Hidiroglu, Ceren
Zugman, Andre
Direk, Nese
Ada, Emel
Cavusoglu, Berrin
Er, Ayşe
Isik, Gizem
Ceylan, Deniz
Tunca, Zeliha
Kempton, Matthew J.
Ozerdem, Aysegul
author_sort Yalin, Nefize
collection PubMed
description OBJECTIVES: So far, few studies have investigated cortical thickness (CT) and surface area (SA) measures in bipolar disorder type I (BDI) in comparison to a high genetic risk group such as first-degree relatives (FR). This study aimed to examine CT and SA differences between BDI, FR and healthy controls (HC). METHODS: 3D T1 magnetic resonance images were acquired from 27 euthymic BDI patients, 24 unaffected FR and 29 HC. CT and SA measures were obtained with FreeSurfer version 5.3.0. Generalized estimating equations were used to compare CT and SA between groups. Group comparisons were repeated with restricting the FR group to 17 siblings (FR-SB) only. RESULTS: \Mean age in years was 36.3 ± 9.5 for BDI, 32.1 ± 10.9 for FR, 34.7 ± 9.8 for FR-SB and 33.1 ± 9.0 for HC group respectively. BDI patients revealed larger SA of left pars triangularis (LPT) compared to HC (p = .001). In addition, increased SA in superior temporal cortex (STC) in FR-SB group compared to HC was identified (p = .0001). CONCLUSIONS: Our result of increased SA in LPT of BDI could be a disease marker and increased SA in STC of FR-SB could be a marker related with resilience to illness.
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spelling pubmed-63708612019-02-21 Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives Yalin, Nefize Saricicek, Aybala Hidiroglu, Ceren Zugman, Andre Direk, Nese Ada, Emel Cavusoglu, Berrin Er, Ayşe Isik, Gizem Ceylan, Deniz Tunca, Zeliha Kempton, Matthew J. Ozerdem, Aysegul Neuroimage Clin Regular Article OBJECTIVES: So far, few studies have investigated cortical thickness (CT) and surface area (SA) measures in bipolar disorder type I (BDI) in comparison to a high genetic risk group such as first-degree relatives (FR). This study aimed to examine CT and SA differences between BDI, FR and healthy controls (HC). METHODS: 3D T1 magnetic resonance images were acquired from 27 euthymic BDI patients, 24 unaffected FR and 29 HC. CT and SA measures were obtained with FreeSurfer version 5.3.0. Generalized estimating equations were used to compare CT and SA between groups. Group comparisons were repeated with restricting the FR group to 17 siblings (FR-SB) only. RESULTS: \Mean age in years was 36.3 ± 9.5 for BDI, 32.1 ± 10.9 for FR, 34.7 ± 9.8 for FR-SB and 33.1 ± 9.0 for HC group respectively. BDI patients revealed larger SA of left pars triangularis (LPT) compared to HC (p = .001). In addition, increased SA in superior temporal cortex (STC) in FR-SB group compared to HC was identified (p = .0001). CONCLUSIONS: Our result of increased SA in LPT of BDI could be a disease marker and increased SA in STC of FR-SB could be a marker related with resilience to illness. Elsevier 2019-01-29 /pmc/articles/PMC6370861/ /pubmed/30738374 http://dx.doi.org/10.1016/j.nicl.2019.101695 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Yalin, Nefize
Saricicek, Aybala
Hidiroglu, Ceren
Zugman, Andre
Direk, Nese
Ada, Emel
Cavusoglu, Berrin
Er, Ayşe
Isik, Gizem
Ceylan, Deniz
Tunca, Zeliha
Kempton, Matthew J.
Ozerdem, Aysegul
Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives
title Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives
title_full Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives
title_fullStr Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives
title_full_unstemmed Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives
title_short Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives
title_sort cortical thickness and surface area as an endophenotype in bipolar disorder type i patients and their first-degree relatives
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370861/
https://www.ncbi.nlm.nih.gov/pubmed/30738374
http://dx.doi.org/10.1016/j.nicl.2019.101695
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