Cargando…

Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat

Diffusion tensor imaging (DTI) has provided remarkable insight into our understanding of white matter microstructure and brain connectivity across a broad spectrum of psychiatric disease. While DTI and other diffusion weighted magnetic resonance imaging (MRI) methods have clarified the axonal contri...

Descripción completa

Detalles Bibliográficos
Autores principales: Barnett, Brian R., Torres-Velázquez, Maribel, Yi, Sue Y., Rowley, Paul A., Sawin, Emily A., Rubinstein, C. Dustin, Krentz, Kathleen, Anderson, Jacqueline M., Bakshi, Vaishali P., Yu, John-Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370885/
https://www.ncbi.nlm.nih.gov/pubmed/30745562
http://dx.doi.org/10.1038/s41398-019-0429-2
_version_ 1783394449586388992
author Barnett, Brian R.
Torres-Velázquez, Maribel
Yi, Sue Y.
Rowley, Paul A.
Sawin, Emily A.
Rubinstein, C. Dustin
Krentz, Kathleen
Anderson, Jacqueline M.
Bakshi, Vaishali P.
Yu, John-Paul J.
author_facet Barnett, Brian R.
Torres-Velázquez, Maribel
Yi, Sue Y.
Rowley, Paul A.
Sawin, Emily A.
Rubinstein, C. Dustin
Krentz, Kathleen
Anderson, Jacqueline M.
Bakshi, Vaishali P.
Yu, John-Paul J.
author_sort Barnett, Brian R.
collection PubMed
description Diffusion tensor imaging (DTI) has provided remarkable insight into our understanding of white matter microstructure and brain connectivity across a broad spectrum of psychiatric disease. While DTI and other diffusion weighted magnetic resonance imaging (MRI) methods have clarified the axonal contribution to the disconnectivity seen in numerous psychiatric diseases, absent from these studies are quantitative indices of neurite density and orientation that are especially important features in regions of high synaptic density that would capture the synaptic contribution to the psychiatric disease state. Here we report the application of neurite orientation dispersion and density imaging (NODDI), an emerging microstructure imaging technique, to a novel Disc1 svΔ2 rat model of psychiatric illness and demonstrate the complementary and more specific indices of tissue microstructure found in NODDI than those reported by DTI. Our results demonstrate global and sex-specific changes in white matter microstructural integrity and deficits in neurite density as a consequence of the Disc1 svΔ2 genetic variation and highlight the application of NODDI and quantitative measures of neurite density and neurite dispersion in psychiatric disease.
format Online
Article
Text
id pubmed-6370885
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-63708852019-02-15 Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat Barnett, Brian R. Torres-Velázquez, Maribel Yi, Sue Y. Rowley, Paul A. Sawin, Emily A. Rubinstein, C. Dustin Krentz, Kathleen Anderson, Jacqueline M. Bakshi, Vaishali P. Yu, John-Paul J. Transl Psychiatry Article Diffusion tensor imaging (DTI) has provided remarkable insight into our understanding of white matter microstructure and brain connectivity across a broad spectrum of psychiatric disease. While DTI and other diffusion weighted magnetic resonance imaging (MRI) methods have clarified the axonal contribution to the disconnectivity seen in numerous psychiatric diseases, absent from these studies are quantitative indices of neurite density and orientation that are especially important features in regions of high synaptic density that would capture the synaptic contribution to the psychiatric disease state. Here we report the application of neurite orientation dispersion and density imaging (NODDI), an emerging microstructure imaging technique, to a novel Disc1 svΔ2 rat model of psychiatric illness and demonstrate the complementary and more specific indices of tissue microstructure found in NODDI than those reported by DTI. Our results demonstrate global and sex-specific changes in white matter microstructural integrity and deficits in neurite density as a consequence of the Disc1 svΔ2 genetic variation and highlight the application of NODDI and quantitative measures of neurite density and neurite dispersion in psychiatric disease. Nature Publishing Group UK 2019-02-11 /pmc/articles/PMC6370885/ /pubmed/30745562 http://dx.doi.org/10.1038/s41398-019-0429-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Barnett, Brian R.
Torres-Velázquez, Maribel
Yi, Sue Y.
Rowley, Paul A.
Sawin, Emily A.
Rubinstein, C. Dustin
Krentz, Kathleen
Anderson, Jacqueline M.
Bakshi, Vaishali P.
Yu, John-Paul J.
Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat
title Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat
title_full Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat
title_fullStr Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat
title_full_unstemmed Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat
title_short Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat
title_sort sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the disc1 gene in the rat
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370885/
https://www.ncbi.nlm.nih.gov/pubmed/30745562
http://dx.doi.org/10.1038/s41398-019-0429-2
work_keys_str_mv AT barnettbrianr sexspecificdeficitsinneuritedensityandwhitematterintegrityareassociatedwithtargeteddisruptionofexon2ofthedisc1geneintherat
AT torresvelazquezmaribel sexspecificdeficitsinneuritedensityandwhitematterintegrityareassociatedwithtargeteddisruptionofexon2ofthedisc1geneintherat
AT yisuey sexspecificdeficitsinneuritedensityandwhitematterintegrityareassociatedwithtargeteddisruptionofexon2ofthedisc1geneintherat
AT rowleypaula sexspecificdeficitsinneuritedensityandwhitematterintegrityareassociatedwithtargeteddisruptionofexon2ofthedisc1geneintherat
AT sawinemilya sexspecificdeficitsinneuritedensityandwhitematterintegrityareassociatedwithtargeteddisruptionofexon2ofthedisc1geneintherat
AT rubinsteincdustin sexspecificdeficitsinneuritedensityandwhitematterintegrityareassociatedwithtargeteddisruptionofexon2ofthedisc1geneintherat
AT krentzkathleen sexspecificdeficitsinneuritedensityandwhitematterintegrityareassociatedwithtargeteddisruptionofexon2ofthedisc1geneintherat
AT andersonjacquelinem sexspecificdeficitsinneuritedensityandwhitematterintegrityareassociatedwithtargeteddisruptionofexon2ofthedisc1geneintherat
AT bakshivaishalip sexspecificdeficitsinneuritedensityandwhitematterintegrityareassociatedwithtargeteddisruptionofexon2ofthedisc1geneintherat
AT yujohnpaulj sexspecificdeficitsinneuritedensityandwhitematterintegrityareassociatedwithtargeteddisruptionofexon2ofthedisc1geneintherat