Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation

T helper type 2 (Th2) cells are important regulators of mammalian adaptive immunity and have relevance for infection, autoimmunity, and tumor immunology. Using a newly developed, genome-wide retroviral CRISPR knockout (KO) library, combined with RNA-seq, ATAC-seq, and ChIP-seq, we have dissected the...

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Detalles Bibliográficos
Autores principales: Henriksson, Johan, Chen, Xi, Gomes, Tomás, Ullah, Ubaid, Meyer, Kerstin B., Miragaia, Ricardo, Duddy, Graham, Pramanik, Jhuma, Yusa, Kosuke, Lahesmaa, Riitta, Teichmann, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370901/
https://www.ncbi.nlm.nih.gov/pubmed/30639098
http://dx.doi.org/10.1016/j.cell.2018.11.044

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