Cargando…

Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment

ROCK-Myosin II drives fast rounded-amoeboid migration in cancer cells during metastatic dissemination. Analysis of human melanoma biopsies revealed that amoeboid melanoma cells with high Myosin II activity are predominant in the invasive fronts of primary tumors in proximity to CD206(+)CD163(+) tumo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Georgouli, Mirella, Herraiz, Cecilia, Crosas-Molist, Eva, Fanshawe, Bruce, Maiques, Oscar, Perdrix, Anna, Pandya, Pahini, Rodriguez-Hernandez, Irene, Ilieva, Kristina M., Cantelli, Gaia, Karagiannis, Panagiotis, Mele, Silvia, Lam, Hoyin, Josephs, Debra H., Matias-Guiu, Xavier, Marti, Rosa M., Nestle, Frank O., Orgaz, Jose L., Malanchi, Ilaria, Fruhwirth, Gilbert O., Karagiannis, Sophia N., Sanz-Moreno, Victoria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370915/ https://www.ncbi.nlm.nih.gov/pubmed/30712866 http://dx.doi.org/10.1016/j.cell.2018.12.038

Ejemplares similares

Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance
por: Orgaz, Jose L., et al.
Publicado: (2020)

TGFΒ-induced transcription in cancer
por: Cantelli, Gaia, et al.
Publicado: (2017)

WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
por: Rodriguez-Hernandez, Irene, et al.
Publicado: (2020)

TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination
por: Cantelli, Gaia, et al.
Publicado: (2015)

A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma
por: Maiques, Oscar, et al.
Publicado: (2021)

Diverse matrix metalloproteinase functions regulate cancer amoeboid migration
por: Orgaz, Jose L., et al.
Publicado: (2014)

AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration
por: Crosas-Molist, Eva, et al.
Publicado: (2023)

Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination
por: Herraiz, Cecilia, et al.
Publicado: (2015)

The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination
por: Crosas-Molist, E, et al.
Publicado: (2017)

Reactive oxygen species and tumor dissemination: Allies no longer
por: Herraiz, Cecilia, et al.
Publicado: (2016)

Actomyosin contractility and collective migration: may the force be with you
por: Pandya, Pahini, et al.
Publicado: (2017)

Modes of invasion during tumour dissemination
por: Pandya, Pahini, et al.
Publicado: (2016)

Recent advances in tissue imaging for cancer research
por: Maiques, Oscar, et al.
Publicado: (2019)

IgG4 antibodies and cancer-associated inflammation: Insights into a novel mechanism of immune escape
por: Karagiannis, Panagiotis, et al.
Publicado: (2013)

CD73 controls Myosin II–driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells
por: Samain, Remi, et al.
Publicado: (2023)

Evaluation of Antigen-Conjugated Fluorescent Beads to Identify Antigen-Specific B Cells
por: Correa, Isabel, et al.
Publicado: (2018)

IgG4 Characteristics and Functions in Cancer Immunity
por: Crescioli, Silvia, et al.
Publicado: (2016)

Role of NADPH oxidases in the redox biology of liver fibrosis
por: Crosas-Molist, Eva, et al.
Publicado: (2015)

Elevated IgG4 in patient circulation is associated with the risk of disease progression in melanoma
por: Karagiannis, Panagiotis, et al.
Publicado: (2015)

B cells and the humoral response in melanoma: The overlooked players of the tumor microenvironment
por: Chiaruttini, Giulia, et al.
Publicado: (2017)

Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)
por: Hoffmann, Ricarda M., et al.
Publicado: (2017)

Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-β-induced epithelial to amoeboid transition
por: López-Luque, Judit, et al.
Publicado: (2019)

IgG subclass switching and clonal expansion in cutaneous melanoma and normal skin
por: Saul, Louise, et al.
Publicado: (2016)

An immunologically relevant rodent model demonstrates safety of therapy using a tumour‐specific IgE
por: Josephs, D. H., et al.
Publicado: (2018)

In vivo safety profile of a CSPG4-directed IgE antibody in an immunocompetent rat model
por: Williams, Iwan P., et al.
Publicado: (2019)

In Planta Glycan Engineering and Functional Activities of IgE Antibodies
por: Montero-Morales, Laura, et al.
Publicado: (2019)

Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields
por: Ilieva, Kristina M., et al.
Publicado: (2017)

Resident CD141 (BDCA3)(+) dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation
por: Chu, Chung-Ching, et al.
Publicado: (2012)

B Lymphocytes Accumulate and Proliferate in Human Skin at Sites of Cutaneous Antigen Challenge
por: Egbuniwe, Isioma U., et al.
Publicado: (2022)

IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states
por: Pellizzari, Giulia, et al.
Publicado: (2019)

Myosins of secretory tissues
Publicado: (1978)

Monitoring the Systemic Human Memory B Cell Compartment of Melanoma Patients for Anti-Tumor IgG Antibodies
por: Gilbert, Amy E., et al.
Publicado: (2011)

In vivo trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart
por: Man, Francis, et al.
Publicado: (2021)

AllergoOncology: Expression platform development and functional profiling of an anti‐HER2 IgE antibody
por: Ilieva, Kristina M., et al.
Publicado: (2019)

Protocol to drive human monocyte-to-macrophage polarization in vitro using tumor conditioned media
por: George, Samantha, et al.
Publicado: (2022)

Rho, ROCK and actomyosin contractility in metastasis as drug targets
por: Rodriguez-Hernandez, Irene, et al.
Publicado: (2016)

A tool kit for rapid cloning and expression of recombinant antibodies
por: Dodev, Tihomir S., et al.
Publicado: (2014)

BRAF inhibitors: resistance and the promise of combination treatments for melanoma
por: Griffin, Merope, et al.
Publicado: (2017)

Evaluating Biomarkers in Melanoma
por: Karagiannis, Panagiotis, et al.
Publicado: (2015)

What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation
por: Orgaz, Jose L, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_trobtumeij2jmtigg1nv6ctko3