Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production

Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon secretion similar to that seen in diabetic patients (too much at high glucose and t...

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Detalles Bibliográficos
Autores principales: Knudsen, Jakob G., Hamilton, Alexander, Ramracheya, Reshma, Tarasov, Andrei I., Brereton, Melissa, Haythorne, Elizabeth, Chibalina, Margarita V., Spégel, Peter, Mulder, Hindrik, Zhang, Quan, Ashcroft, Frances M., Adam, Julie, Rorsman, Patrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370947/
https://www.ncbi.nlm.nih.gov/pubmed/30415925
http://dx.doi.org/10.1016/j.cmet.2018.10.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370947/
https://www.ncbi.nlm.nih.gov/pubmed/30415925
http://dx.doi.org/10.1016/j.cmet.2018.10.003

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