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Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment()
Primary central nervous system lymphoma (PCNSL) is a group of extranodal non-Hodgkin lymphoma that exhibits specific biological characteristics and clinical behavior, with an aggressive disease course and unsatisfactory patient outcomes. It is of great importance to identify aberrant genetic loci an...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371000/ https://www.ncbi.nlm.nih.gov/pubmed/30616219 http://dx.doi.org/10.1016/j.tranon.2018.11.011 |
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author | Cai, Qingqing Fang, Yu Young, Ken H. |
author_facet | Cai, Qingqing Fang, Yu Young, Ken H. |
author_sort | Cai, Qingqing |
collection | PubMed |
description | Primary central nervous system lymphoma (PCNSL) is a group of extranodal non-Hodgkin lymphoma that exhibits specific biological characteristics and clinical behavior, with an aggressive disease course and unsatisfactory patient outcomes. It is of great importance to identify aberrant genetic loci and important molecular pathways that might suggest potential targets for new therapeutics and provide prognostic information. In this review, we listed various genetic and epigenetic alterations that are involved in PCNSL pathogenesis. In the aspect of treatment, we summarized the related literatures and evaluated the efficacy of surgery, induction chemotherapy, radiotherapy, intrathecal chemotherapy, and autologous stem cell transplantation in PCNSL. We also proposed the possible new agents for recurrent and relapse PCNSL based on the result of recent clinical researches. |
format | Online Article Text |
id | pubmed-6371000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Neoplasia Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-63710002019-02-21 Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment() Cai, Qingqing Fang, Yu Young, Ken H. Transl Oncol Review article Primary central nervous system lymphoma (PCNSL) is a group of extranodal non-Hodgkin lymphoma that exhibits specific biological characteristics and clinical behavior, with an aggressive disease course and unsatisfactory patient outcomes. It is of great importance to identify aberrant genetic loci and important molecular pathways that might suggest potential targets for new therapeutics and provide prognostic information. In this review, we listed various genetic and epigenetic alterations that are involved in PCNSL pathogenesis. In the aspect of treatment, we summarized the related literatures and evaluated the efficacy of surgery, induction chemotherapy, radiotherapy, intrathecal chemotherapy, and autologous stem cell transplantation in PCNSL. We also proposed the possible new agents for recurrent and relapse PCNSL based on the result of recent clinical researches. Neoplasia Press 2019-01-04 /pmc/articles/PMC6371000/ /pubmed/30616219 http://dx.doi.org/10.1016/j.tranon.2018.11.011 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review article Cai, Qingqing Fang, Yu Young, Ken H. Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment() |
title | Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment() |
title_full | Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment() |
title_fullStr | Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment() |
title_full_unstemmed | Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment() |
title_short | Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment() |
title_sort | primary central nervous system lymphoma: molecular pathogenesis and advances in treatment() |
topic | Review article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371000/ https://www.ncbi.nlm.nih.gov/pubmed/30616219 http://dx.doi.org/10.1016/j.tranon.2018.11.011 |
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