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(90)Y SPECT/CT quantitative study and comparison of uptake with pretreatment (99 m)Tc‐MAA SPECT/CT in radiomicrosphere therapy

INTRODUCTION: Yttrium‐90 ((90)Y) microsphere post‐treatment imaging reflects the true distribution characteristics of microspheres in the tumor and liver compartments. However, due to its decay spectra profile lacking a pronounced photopeak, the bremsstrahlung imaging for (90)Y has inherent limitati...

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Autores principales: Debebe, Senait Aknaw, Adjouadi, Malek, Gulec, Seza A., Franquiz, Juan, McGoron, Anthony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371018/
https://www.ncbi.nlm.nih.gov/pubmed/30628156
http://dx.doi.org/10.1002/acm2.12512
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author Debebe, Senait Aknaw
Adjouadi, Malek
Gulec, Seza A.
Franquiz, Juan
McGoron, Anthony J.
author_facet Debebe, Senait Aknaw
Adjouadi, Malek
Gulec, Seza A.
Franquiz, Juan
McGoron, Anthony J.
author_sort Debebe, Senait Aknaw
collection PubMed
description INTRODUCTION: Yttrium‐90 ((90)Y) microsphere post‐treatment imaging reflects the true distribution characteristics of microspheres in the tumor and liver compartments. However, due to its decay spectra profile lacking a pronounced photopeak, the bremsstrahlung imaging for (90)Y has inherent limitations. The absorbed dose calculations for (90)Y microspheres radiomicrosphere therapy (RMT) sustain a limitation due to the poor quality of (90)Y imaging. The aim of this study was to develop quantitative methods to improve the post‐treatment (90)Y bremsstrahlung single photon emission tomography (SPECT)/computed tomography (CT) image analysis for dosimetric purposes and to perform a quantitative comparison with the (99m)Tc‐MAA SPECT/CT images, which is used for theranostics purposes for liver and tumor dosimetry. METHODS: Pre and post‐treatment SPECT/CT data of patients who underwent RMT for primary or metastatic liver cancer were acquired. A Jasczak phantom with eight spherical inserts of various sizes was used to obtain optimal iteration number for the contrast recovery algorithm for improving (90)Y bremsstrahlung SPECT/CT images. Comparison of uptake on (99m)Tc‐MAA and (90)Y microsphere SPECT/CT images was assessed using tumor to healthy liver ratios (TLRs). The voxel dosimetry technique was used to estimate absorbed doses. Absorbed doses within the tumor and healthy part of the liver were also investigated for correlation with administered activity. RESULTS: Improvement in CNR and contrast recovery coefficients on patient and phantom (90)Y bremsstrahlung SPECT/CT images respectively were achieved. The (99m)Tc‐MAA and (90)Y microspheres SPECT/CT images showed significant uptake correlation (r = 0.9, P = 0.05) with mean TLR of 9.4 ± 9.2 and 5.0 ± 2.2, respectively. The correlation between the administered activity and tumor absorbed dose was weak (r = 0.5, P > 0.05), however, healthy liver absorbed dose increased with administered activity (r = 0.8, P = 0.0). CONCLUSIONS: This study demonstrated correlation in mean TLR between (99m)Tc‐MAA and (90)Y microsphere SPECT/CT.
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spelling pubmed-63710182019-02-21 (90)Y SPECT/CT quantitative study and comparison of uptake with pretreatment (99 m)Tc‐MAA SPECT/CT in radiomicrosphere therapy Debebe, Senait Aknaw Adjouadi, Malek Gulec, Seza A. Franquiz, Juan McGoron, Anthony J. J Appl Clin Med Phys Radiation Oncology Physics INTRODUCTION: Yttrium‐90 ((90)Y) microsphere post‐treatment imaging reflects the true distribution characteristics of microspheres in the tumor and liver compartments. However, due to its decay spectra profile lacking a pronounced photopeak, the bremsstrahlung imaging for (90)Y has inherent limitations. The absorbed dose calculations for (90)Y microspheres radiomicrosphere therapy (RMT) sustain a limitation due to the poor quality of (90)Y imaging. The aim of this study was to develop quantitative methods to improve the post‐treatment (90)Y bremsstrahlung single photon emission tomography (SPECT)/computed tomography (CT) image analysis for dosimetric purposes and to perform a quantitative comparison with the (99m)Tc‐MAA SPECT/CT images, which is used for theranostics purposes for liver and tumor dosimetry. METHODS: Pre and post‐treatment SPECT/CT data of patients who underwent RMT for primary or metastatic liver cancer were acquired. A Jasczak phantom with eight spherical inserts of various sizes was used to obtain optimal iteration number for the contrast recovery algorithm for improving (90)Y bremsstrahlung SPECT/CT images. Comparison of uptake on (99m)Tc‐MAA and (90)Y microsphere SPECT/CT images was assessed using tumor to healthy liver ratios (TLRs). The voxel dosimetry technique was used to estimate absorbed doses. Absorbed doses within the tumor and healthy part of the liver were also investigated for correlation with administered activity. RESULTS: Improvement in CNR and contrast recovery coefficients on patient and phantom (90)Y bremsstrahlung SPECT/CT images respectively were achieved. The (99m)Tc‐MAA and (90)Y microspheres SPECT/CT images showed significant uptake correlation (r = 0.9, P = 0.05) with mean TLR of 9.4 ± 9.2 and 5.0 ± 2.2, respectively. The correlation between the administered activity and tumor absorbed dose was weak (r = 0.5, P > 0.05), however, healthy liver absorbed dose increased with administered activity (r = 0.8, P = 0.0). CONCLUSIONS: This study demonstrated correlation in mean TLR between (99m)Tc‐MAA and (90)Y microsphere SPECT/CT. John Wiley and Sons Inc. 2019-01-09 /pmc/articles/PMC6371018/ /pubmed/30628156 http://dx.doi.org/10.1002/acm2.12512 Text en © 2019 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Debebe, Senait Aknaw
Adjouadi, Malek
Gulec, Seza A.
Franquiz, Juan
McGoron, Anthony J.
(90)Y SPECT/CT quantitative study and comparison of uptake with pretreatment (99 m)Tc‐MAA SPECT/CT in radiomicrosphere therapy
title (90)Y SPECT/CT quantitative study and comparison of uptake with pretreatment (99 m)Tc‐MAA SPECT/CT in radiomicrosphere therapy
title_full (90)Y SPECT/CT quantitative study and comparison of uptake with pretreatment (99 m)Tc‐MAA SPECT/CT in radiomicrosphere therapy
title_fullStr (90)Y SPECT/CT quantitative study and comparison of uptake with pretreatment (99 m)Tc‐MAA SPECT/CT in radiomicrosphere therapy
title_full_unstemmed (90)Y SPECT/CT quantitative study and comparison of uptake with pretreatment (99 m)Tc‐MAA SPECT/CT in radiomicrosphere therapy
title_short (90)Y SPECT/CT quantitative study and comparison of uptake with pretreatment (99 m)Tc‐MAA SPECT/CT in radiomicrosphere therapy
title_sort (90)y spect/ct quantitative study and comparison of uptake with pretreatment (99 m)tc‐maa spect/ct in radiomicrosphere therapy
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371018/
https://www.ncbi.nlm.nih.gov/pubmed/30628156
http://dx.doi.org/10.1002/acm2.12512
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