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Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens
Faced with the global health threat of increasing resistance to antibiotics, researchers are exploring interventions that target bacterial virulence factors. Quorum sensing is a particularly attractive target because several bacterial virulence factors are controlled by this mechanism. Furthermore,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371041/ https://www.ncbi.nlm.nih.gov/pubmed/30805311 http://dx.doi.org/10.3389/fcimb.2018.00444 |
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author | Fleitas Martínez, Osmel Rigueiras, Pietra Orlandi Pires, Állan da Silva Porto, William Farias Silva, Osmar Nascimento de la Fuente-Nunez, Cesar Franco, Octavio Luiz |
author_facet | Fleitas Martínez, Osmel Rigueiras, Pietra Orlandi Pires, Állan da Silva Porto, William Farias Silva, Osmar Nascimento de la Fuente-Nunez, Cesar Franco, Octavio Luiz |
author_sort | Fleitas Martínez, Osmel |
collection | PubMed |
description | Faced with the global health threat of increasing resistance to antibiotics, researchers are exploring interventions that target bacterial virulence factors. Quorum sensing is a particularly attractive target because several bacterial virulence factors are controlled by this mechanism. Furthermore, attacking the quorum-sensing signaling network is less likely to select for resistant strains than using conventional antibiotics. Strategies that focus on the inhibition of quorum-sensing signal production are especially attractive because the enzymes involved are expressed in bacterial cells but are not present in their mammalian counterparts. We review here various approaches that are being taken to interfere with quorum-sensing signal production via the inhibition of autoinducer-2 synthesis, PQS synthesis, peptide autoinducer synthesis, and N-acyl-homoserine lactone synthesis. We expect these approaches will lead to the discovery of new quorum-sensing inhibitors that can help to stem the tide of antibiotic resistance. |
format | Online Article Text |
id | pubmed-6371041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63710412019-02-25 Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens Fleitas Martínez, Osmel Rigueiras, Pietra Orlandi Pires, Állan da Silva Porto, William Farias Silva, Osmar Nascimento de la Fuente-Nunez, Cesar Franco, Octavio Luiz Front Cell Infect Microbiol Cellular and Infection Microbiology Faced with the global health threat of increasing resistance to antibiotics, researchers are exploring interventions that target bacterial virulence factors. Quorum sensing is a particularly attractive target because several bacterial virulence factors are controlled by this mechanism. Furthermore, attacking the quorum-sensing signaling network is less likely to select for resistant strains than using conventional antibiotics. Strategies that focus on the inhibition of quorum-sensing signal production are especially attractive because the enzymes involved are expressed in bacterial cells but are not present in their mammalian counterparts. We review here various approaches that are being taken to interfere with quorum-sensing signal production via the inhibition of autoinducer-2 synthesis, PQS synthesis, peptide autoinducer synthesis, and N-acyl-homoserine lactone synthesis. We expect these approaches will lead to the discovery of new quorum-sensing inhibitors that can help to stem the tide of antibiotic resistance. Frontiers Media S.A. 2019-02-05 /pmc/articles/PMC6371041/ /pubmed/30805311 http://dx.doi.org/10.3389/fcimb.2018.00444 Text en Copyright © 2019 Fleitas Martínez, Rigueiras, Pires, Porto, Silva, de la Fuente-Nunez and Franco. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Fleitas Martínez, Osmel Rigueiras, Pietra Orlandi Pires, Állan da Silva Porto, William Farias Silva, Osmar Nascimento de la Fuente-Nunez, Cesar Franco, Octavio Luiz Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens |
title | Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens |
title_full | Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens |
title_fullStr | Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens |
title_full_unstemmed | Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens |
title_short | Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens |
title_sort | interference with quorum-sensing signal biosynthesis as a promising therapeutic strategy against multidrug-resistant pathogens |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371041/ https://www.ncbi.nlm.nih.gov/pubmed/30805311 http://dx.doi.org/10.3389/fcimb.2018.00444 |
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