Cargando…

Combination Therapy With Fingolimod and Neural Stem Cells Promotes Functional Myelination in vivo Through a Non-immunomodulatory Mechanism

Myelination, which occurs predominantly postnatally and continues throughout life, is important for proper neurologic function of the mammalian central nervous system (CNS). We have previously demonstrated that the combination therapy of fingolimod (FTY720) and transplanted neural stem cells (NSCs)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yuan, Lu, Xin-Yu, Ye, Ze-Qin, Ciric, Bogoljub, Ma, Cun-Gen, Rostami, Abdolmohamad, Li, Xing, Zhang, Guang-Xian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371042/ https://www.ncbi.nlm.nih.gov/pubmed/30804753 http://dx.doi.org/10.3389/fncel.2019.00014

Ejemplares similares

Corrigendum: Combination therapy with fingolimod and neural stem cells promotes functional myelination in vivo through a non-immunomodulatory mechanism
por: Zhang, Yuan, et al.
Publicado: (2022)

Neural Stem Cells Engineered to Express Three Therapeutic Factors Mediate Recovery from Chronic Stage CNS Autoimmunity
por: Li, Xing, et al.
Publicado: (2016)

Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway
por: Zhang, Yuan, et al.
Publicado: (2015)

CRISPR-mediated rapid generation of neural cell-specific knockout mice facilitates research in neurophysiology and pathology
por: Xiao, Dan, et al.
Publicado: (2021)

Bone marrow dendritic cells deficient for CD40 and IL-23p19 are tolerogenic in vitro
por: Kalantari, Tahereh, et al.
Publicado: (2020)

A serine protease inhibitor induces type 1 regulatory T cells through IFN-γ/STAT1 signaling
por: Safavi, Farinaz, et al.
Publicado: (2020)

Transcription Factor RUNX3 Mediates Plasticity of ThGM Cells Toward Th1 Phenotype
por: Rasouli, Javad, et al.
Publicado: (2022)

Comprehensive Analysis of the Immune and Stromal Compartments of the CNS in EAE Mice Reveal Pathways by Which Chloroquine Suppresses Neuroinflammation
por: Thome, Rodolfo, et al.
Publicado: (2020)

Chloroquine reduces Th17 cell differentiation by stimulating T-bet expression in T cells
por: Thome, Rodolfo, et al.
Publicado: (2020)

Induction of Peripheral Tolerance in Ongoing Autoimmune Inflammation Requires Interleukin 27 Signaling in Dendritic Cells
por: Thomé, Rodolfo, et al.
Publicado: (2017)

SIRT1 inactivation switches reactive astrocytes to an antiinflammatory phenotype in CNS autoimmunity
por: Zhang, Weifeng, et al.
Publicado: (2022)

Inhibitory effect of IL-17 on neural stem cell proliferation and neural cell differentiation
por: Li, Zichen, et al.
Publicado: (2013)

Interferon-γ/Interleukin-27 Axis Induces Programmed Death Ligand 1 Expression in Monocyte-Derived Dendritic Cells and Restores Immune Tolerance in Central Nervous System Autoimmunity
por: Casella, Giacomo, et al.
Publicado: (2020)

Distinct Role of IL-27 in Immature and LPS-Induced Mature Dendritic Cell-Mediated Development of CD4(+) CD127(+)3G11(+) Regulatory T Cell Subset
por: Zhou, Fang, et al.
Publicado: (2018)

GATA1 controls numbers of hematopoietic progenitors and their response to autoimmune neuroinflammation
por: Hwang, Daniel, et al.
Publicado: (2022)

CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation
por: Hwang, Daniel, et al.
Publicado: (2022)

Mediastinal abscess and osteomyelitis as side effects of immunomodulatory treatment with fingolimod
por: Eforakopoulos, Fotios, et al.
Publicado: (2022)

Evaluation of the effect of GM-CSF blocking on the phenotype and function of human monocytes
por: Lotfi, Noushin, et al.
Publicado: (2020)

Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis
por: Li, Yan-Hua, et al.
Publicado: (2019)

IFN-β Acts on Monocytes to Ameliorate CNS Autoimmunity by Inhibiting Proinflammatory Cross-Talk Between Monocytes and Th Cells
por: Rasouli, Javad, et al.
Publicado: (2021)

Dimethyl fumarate suppresses granulocyte macrophage colony-stimulating factor–producing Th1 cells in CNS neuroinflammation
por: Safavi, Farinaz, et al.
Publicado: (2020)

Characterization of the effects of immunomodulatory drug fingolimod (FTY720) on human T cell receptor signaling pathways
por: Baer, Alan, et al.
Publicado: (2018)

Effects of FTY720 (Fingolimod) on Proliferation, Differentiation, and Migration of Brain-Derived Neural Stem Cells
por: Tan, Botao, et al.
Publicado: (2016)

Roles of GM-CSF in the Pathogenesis of Autoimmune Diseases: An Update
por: Lotfi, Noushin, et al.
Publicado: (2019)

Identifying Genes that Affect Differentiation of Human Neural Stem Cells and Myelination of Mature Oligodendrocytes
por: Ye, Dou, et al.
Publicado: (2022)

Determination of Seminal Concentration of Fingolimod and Fingolimod‐Phosphate in Multiple Sclerosis Patients Receiving Chronic Treatment With Fingolimod
por: David, Olivier J., et al.
Publicado: (2017)

Potential roles of extracellular vesicles in the pathophysiology, diagnosis, and treatment of autoimmune diseases
por: Tian, Jing, et al.
Publicado: (2020)

Fingolimod Enhances Oligodendrocyte Differentiation of Transplanted Human Induced Pluripotent Stem Cell-Derived Neural Progenitors
por: Yazdi, Azadeh, et al.
Publicado: (2018)

Heterogeneous populations of neural stem cells contribute to myelin repair
por: Akkermann, Rainer, et al.
Publicado: (2017)

Magnetic Resonance of Myelin Water: An in vivo Marker for Myelin
por: MacKay, Alex L., et al.
Publicado: (2016)

MS4a4B, a CD20 Homologue in T Cells, Inhibits T Cell Propagation by Modulation of Cell Cycle
por: Xu, Hui, et al.
Publicado: (2010)

IN VIVO AND IN VITRO IMMUNOMODULATORY AND ANTI-INFLAMMATORY EFFECTS OF TOTAL FLAVONOIDS OF ASTRAGALUS
por: Guo, Ze, et al.
Publicado: (2016)

Immunomodulatory drug fingolimod (FTY720) restricts the growth of opportunistic yeast Candida albicans in vitro and in a mouse candidiasis model
por: Najarzadegan, Niloofar, et al.
Publicado: (2022)

Myelination and Isochronicity in Neural Networks
por: Kimura, Fumitaka, et al.
Publicado: (2009)

Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis
por: Sarma, Jayasri Das, et al.
Publicado: (2009)

Coseeded Schwann cells myelinate neurites from differentiated neural stem cells in neurotrophin-3-loaded PLGA carriers
por: Xiong, Yi, et al.
Publicado: (2012)

The Long Road of Immunotherapeutics against Multiple Sclerosis †
por: Apostolopoulos, Vasso, et al.
Publicado: (2020)

Editorial: Physiology of Myelin Forming Cells, From Myelination to Neural Modulators
por: Baraban, Marion, et al.
Publicado: (2019)

Generation of Oligodendrocyte Progenitor Cells From Mouse Bone Marrow Cells
por: Zhang, Yuan, et al.
Publicado: (2019)

Antidepressant activity of fingolimod in mice
por: di Nuzzo, Luigi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_orakc7ufc1f06paatrkrtjn56f