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IGFBP-3 Induced by Ribotoxic Stress Traffics From the Endoplasmic Reticulum to the Nucleus in Mammary Epithelial Cells

IGF-binding protein (IGFBP)-3 is a multifunctional protein that can exert IGF-independent effects on apoptosis. Anisomycin (ANS) is a potent inducer of IGFBP-3 production in bovine mammary epithelial cells (MECs), and knockdown of IGFBP-3 attenuates ANS-induced apoptosis. IGFBP-3 is present in the n...

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Detalles Bibliográficos
Autores principales:	Agostini-Dreyer, Allyson, Jetzt, Amanda E, Skorupa, Jennifer, Hanke, Jennifer, Cohick, Wendie S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371081/ https://www.ncbi.nlm.nih.gov/pubmed/30788454 http://dx.doi.org/10.1210/js.2018-00330

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