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Obesity, Physical Fitness and Inflammation in the Elderly

Among the elderly, obesity is paradoxically associated with a lower mortality risk. Thus, this study describes fitness levels by Body Mass Index (BMI) category and the associations of high-sensitivity C-reactive protein (hs-CRP) and Vitamin D levels with muscle strength, in community-dwelling older...

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Autores principales: Silva, Bruno, Camões, Miguel, Simões, Mário, Bezerra, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371162/
https://www.ncbi.nlm.nih.gov/pubmed/31011040
http://dx.doi.org/10.3390/geriatrics2040030
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author Silva, Bruno
Camões, Miguel
Simões, Mário
Bezerra, Pedro
author_facet Silva, Bruno
Camões, Miguel
Simões, Mário
Bezerra, Pedro
author_sort Silva, Bruno
collection PubMed
description Among the elderly, obesity is paradoxically associated with a lower mortality risk. Thus, this study describes fitness levels by Body Mass Index (BMI) category and the associations of high-sensitivity C-reactive protein (hs-CRP) and Vitamin D levels with muscle strength, in community-dwelling older adults. A cross-sectional study, with 1338 subjects having mean age of 78.3 years, were assessed in anthropometrics, muscle strength, and cardiorespiratory fitness. In a sub-sample, blood samples were collected and objective markers of inflammation were provided: high-sensitivity C-reactive protein (hs-CRP) and Vitamin D (25(OH) D). Obese women (BMI ≥ 30.0 kg/m(2)) showed significantly better results for grip strength than normal weight group (BMI between 18.5–24.9 kg/m(2)): 22.3 (7.0) vs. 20.0 (6.8); p = 0.002. After adjustment, higher levels of hs-CRP were an independent predictor of lower levels of grip strength (β = −0.213, 95% CI: −0.424; −0.002) and Vitamin D levels were positively associated with higher levels of muscle strength (β = 0.098, 95% CI: 0.008–0.189). The multivariate analysis found a significant and positive association between 25(OH) D and grip strength: (β = 0.098, 95% CI: 0.008–0.189). A positive pattern of higher levels of absolute strength among obese older subjects could have an important impact on morbidity and mortality risk, through the inverse association with acute inflammation and an increase in Vitamin D profile.
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spelling pubmed-63711622019-03-07 Obesity, Physical Fitness and Inflammation in the Elderly Silva, Bruno Camões, Miguel Simões, Mário Bezerra, Pedro Geriatrics (Basel) Article Among the elderly, obesity is paradoxically associated with a lower mortality risk. Thus, this study describes fitness levels by Body Mass Index (BMI) category and the associations of high-sensitivity C-reactive protein (hs-CRP) and Vitamin D levels with muscle strength, in community-dwelling older adults. A cross-sectional study, with 1338 subjects having mean age of 78.3 years, were assessed in anthropometrics, muscle strength, and cardiorespiratory fitness. In a sub-sample, blood samples were collected and objective markers of inflammation were provided: high-sensitivity C-reactive protein (hs-CRP) and Vitamin D (25(OH) D). Obese women (BMI ≥ 30.0 kg/m(2)) showed significantly better results for grip strength than normal weight group (BMI between 18.5–24.9 kg/m(2)): 22.3 (7.0) vs. 20.0 (6.8); p = 0.002. After adjustment, higher levels of hs-CRP were an independent predictor of lower levels of grip strength (β = −0.213, 95% CI: −0.424; −0.002) and Vitamin D levels were positively associated with higher levels of muscle strength (β = 0.098, 95% CI: 0.008–0.189). The multivariate analysis found a significant and positive association between 25(OH) D and grip strength: (β = 0.098, 95% CI: 0.008–0.189). A positive pattern of higher levels of absolute strength among obese older subjects could have an important impact on morbidity and mortality risk, through the inverse association with acute inflammation and an increase in Vitamin D profile. MDPI 2017-09-21 /pmc/articles/PMC6371162/ /pubmed/31011040 http://dx.doi.org/10.3390/geriatrics2040030 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Silva, Bruno
Camões, Miguel
Simões, Mário
Bezerra, Pedro
Obesity, Physical Fitness and Inflammation in the Elderly
title Obesity, Physical Fitness and Inflammation in the Elderly
title_full Obesity, Physical Fitness and Inflammation in the Elderly
title_fullStr Obesity, Physical Fitness and Inflammation in the Elderly
title_full_unstemmed Obesity, Physical Fitness and Inflammation in the Elderly
title_short Obesity, Physical Fitness and Inflammation in the Elderly
title_sort obesity, physical fitness and inflammation in the elderly
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371162/
https://www.ncbi.nlm.nih.gov/pubmed/31011040
http://dx.doi.org/10.3390/geriatrics2040030
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