Thromboxane–prostaglandin receptor antagonist, terutroban, prevents neurovascular events after subarachnoid haemorrhage: a nanoSPECT study in rats

BACKGROUND: Several lipid metabolites in cerebrospinal fluid are correlated with poor outcomes in aneurysmal subarachnoid haemorrhage. Most of these metabolites bind to ubiquitous thromboxane–prostaglandin (TP) receptors, causing vasoconstriction and inflammation. Here, we evaluated terutroban (TBN)...

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Detalles Bibliográficos
Autores principales: Lagier, David, Tonon, David, Garrigue, Philippe, Guillet, Benjamin, Giacomino, Laura, Martin, Jean-Charles, Alessi, Marie-Christine, Bruder, Nicolas, Velly, Lionel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371436/
https://www.ncbi.nlm.nih.gov/pubmed/30744667
http://dx.doi.org/10.1186/s13054-019-2338-4

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