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Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity
BACKGROUND: Alternative splicing is a key regulatory mechanism in eukaryotic cells and increases the effective number of functionally distinct gene products. Using bulk RNA sequencing, splicing variation has been studied across human tissues and in genetically diverse populations. This has identifie...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371455/ https://www.ncbi.nlm.nih.gov/pubmed/30744673 http://dx.doi.org/10.1186/s13059-019-1644-0 |